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Intragastric balloon for weight loss: results in 100 individuals followed for at least 2.5 years

Dastis, Negrin S.
François, E.
Deviere, J.
Hittelet, A.
Ilah Mehdi, A.
Barea, M.
Published in Endoscopy. 2009, vol. 41, no. 7, p. 575-580
Abstract BACKGROUND AND STUDY AIMS: To determine long-term outcome after treatment with an intragastric balloon for 6 months, with no structured weight maintenance program offered after balloon removal. PATIENTS AND METHODS: 100 consecutive overweight/obese individuals (mean body mass index [BMI] 35.0 +/- 5.6 kg/m (2)) were prospectively followed after endoscopic implantation of a saline-filled intragastric balloon; 97 completed final follow-up at a mean of 4.8 +/- 1.6 years. Successful intragastric balloon therapy was defined as weight loss at 6 months of ≥ 10 % of weight at baseline, that remained ≥ 10 % until 2.5 years, without bariatric surgery. All analyses followed intention-to-treat principles. RESULTS: At 6 months, mean weight loss was 12.6 +/- 8.3 kg, 63 individuals had ≥ 10 % baseline weight loss; no severe morbidity was detected. During the first and second years following intragastric balloon removal, mean body mass increased by 4.2 +/- 6.8 and 2.3 +/- 6.0 kg, respectively ( P < 0.001 for both year-on-year comparisons). At 2.5 years, intragastric balloon therapy had been successful in 24 participants. At final follow-up (4.8 +/- 1.6 years), 28 had ≥ 10 % baseline weight loss, 35 had undergone bariatric surgery (60 % had preoperative mass higher than baseline), and 3 were lost to follow-up; the 34 remaining had lost 1.5 +/- 5.8 kg compared with baseline. During follow-up, 13 had a second intragastric balloon implanted and 13 took sibutramine for short periods. CONCLUSION: Intragastric balloon therapy was relatively innocuous and associated with successful weight loss and maintenance at 2.5 years in a quarter of participants. It represents a valid option for weight loss.
Keywords AdultBody Mass IndexDevice RemovalEndoscopyFemaleFollow-Up Studies*Gastric BalloonHumansMaleMiddle AgedObesity/*therapyProspective StudiesTime FactorsTreatment Outcome*Weight Loss
PMID: 19588283
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DASTIS, Negrin S. et al. Intragastric balloon for weight loss: results in 100 individuals followed for at least 2.5 years. In: Endoscopy, 2009, vol. 41, n° 7, p. 575-580. doi: 10.1055/s-0029-1214826 https://archive-ouverte.unige.ch/unige:19758

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Deposited on : 2012-04-23

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