en
Scientific article
Review
English

Clinical follow-up of women infected with human papillomavirus-16, either alone or with other human papillomavirus types: identification of different risk groups

Published inAmerican journal of obstetrics and gynecology, vol. 200, no. 3, p. 286e281-286
Publication date2009
Abstract

OBJECTIVES: Evaluation of the clinical impact of multiple infections of the cervix by human papillomavirus, including human papillomavirus-16, compared with single human papillomavirus-16 infection. STUDY DESIGN: One hundred sixty-nine women were classified in 3 categories depending on their human papillomavirus profile: human papillomavirus-16 only, human papillomavirus-16 and low-risk type(s), and human papillomavirus-16 and other high-risk type(s). Cervical brush samples were analyzed for human papillomavirus DNA by polymerase chain reaction and reverse line blot hybridization. All women were evaluated with colposcopy during 24 months or more. Management was according to the Bethesda recommendations. RESULTS: Women infected with human papillomavirus-16 and other high-risk human papillomavirus type(s) presented more progression or no change in the grade of dysplasia, compared with women of the other groups (relative risk [RR], 1.39; 95% confidence interval [CI], 1.07-1.82; P = .02 at 6 months; RR, 2.10; 95% CI, 1.46-3.02; P < .001 at 12 months; RR, 1.82; 95% CI, 1.21-2.72; P = .004 at 24 months). CONCLUSION: Coinfection of women with human papillomavirus-16 and other high-risk human papillomavirus type(s) increases the risk of unfavorable evolution.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Colposcopy
  • DNA, Viral
  • Female
  • Follow-Up Studies
  • Genotype
  • Human papillomavirus 16/*genetics
  • Humans
  • Middle Aged
  • Papillomaviridae/genetics
  • Papillomavirus Infections/*epidemiology/pathology
  • Retrospective Studies
  • Risk Factors
  • Uterine Cervical Dysplasia/epidemiology/pathology/virology
  • Uterine Cervical Neoplasms/*epidemiology/pathology/*virology
  • Vaginal Smears
  • Young Adult
Citation (ISO format)
COTTIER, Olivier et al. Clinical follow-up of women infected with human papillomavirus-16, either alone or with other human papillomavirus types: identification of different risk groups. In: American journal of obstetrics and gynecology, 2009, vol. 200, n° 3, p. 286e281–286. doi: 10.1016/j.ajog.2008.10.011
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0002-9378
555views
0downloads

Technical informations

Creation04/23/2012 1:23:17 PM
First validation04/23/2012 1:23:17 PM
Update time03/14/2023 5:24:34 PM
Status update03/14/2023 5:24:34 PM
Last indexation02/12/2024 7:57:23 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack