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Title

Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale

Authors
Rudhard-Thomazic, Valérie
Published in Journal of the Neurological Sciences. 2009, vol. 283, no. 1-2, p. 69-72
Abstract To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.
Keywords AgedAged, 80 and overDementia/*psychology/therapyDepression/*diagnosis/therapyDepressive Disorder/*diagnosis/therapyFemaleHospitalizationHumansMaleMiddle Aged*Psychiatric Status Rating ScalesROC CurveSensitivity and SpecificitySocioeconomic FactorsTreatment Outcome
Identifiers
PMID: 19261298
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Research group Groupe Giannakopoulos Panteleimon (psychiatrie générale) (201)
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(ISO format)
CANUTO, Alessandra et al. Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale. In: Journal of the Neurological Sciences, 2009, vol. 283, n° 1-2, p. 69-72. https://archive-ouverte.unige.ch/unige:19727

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Deposited on : 2012-04-23

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