Scientific article

Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients

Published inEuropean neurology, vol. 62, no. 4, p. 243-249
Publication date2009

BACKGROUND: Modafinil has anecdotal response to neurological fatigue, but such an effect may depend on the type and location of cerebral impairment. OBJECTIVES: It was the aim of this study to compare fatigue observed in different neurological pathologies, to evaluate the tolerability to modafinil, and to describe changes in subjective fatigue. METHODS: We enrolled 14 brainstem or diencephalic stroke (BDS) patients, 9 cortical stroke (CS) patients and 17 multiple sclerosis (MS) patients. The Fatigue Assessment Instrument severity scale was performed at baseline, after 3 months of modafinil and after 1 month of washout. Cognition, mood and somnolence were assessed. A subgroup of 14 patients underwent activity measures before and during treatment. RESULTS: Thirty-one patients completed the study (10 BDS, 9 CS, 12 MS). The responder profile is more frequent in MS than in CS (p = 0.04), and in BDS than in CS patients (p = 0.04). Actiwatch measures showed no changes in activity during, before and after therapy. CONCLUSION: Modafinil was tolerated in 75% of patients at small doses and seemed to improve the severity of fatigue in the MS and BDS groups but not in the CS group. There was no modification in measured physical activity.

  • Adult
  • Benzhydryl Compounds/adverse effects/*therapeutic use
  • Central Nervous System Stimulants/therapeutic use
  • Dose-Response Relationship, Drug
  • Fatigue/*complications/*drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis/*complications
  • Neuropsychological Tests
  • Patient Selection
  • Psychiatric Status Rating Scales
  • Questionnaires
  • Severity of Illness Index
  • Sleep/drug effects
  • Stroke/*complications
  • Treatment Outcome
  • Wakefulness/drug effects
Citation (ISO format)
BRIOSCHI, Andrea et al. Effect of modafinil on subjective fatigue in multiple sclerosis and stroke patients. In: European neurology, 2009, vol. 62, n° 4, p. 243–249. doi: 10.1159/000232927
Main files (1)
ISSN of the journal0014-3022

Technical informations

Creation04/23/2012 1:23:03 PM
First validation04/23/2012 1:23:03 PM
Update time03/14/2023 5:24:16 PM
Status update03/14/2023 5:24:16 PM
Last indexation02/12/2024 7:56:27 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack