UNIGE document Scientific Article
previous document  unige:19707  next document
add to browser collection

Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2

Schindler, C.
Dietrich, D Felber
Curjuric, I.
Dratva, J.
Ackermann-Liebrich, Ursula
Probst-Hensch, N. M.
show hidden authors show all authors [1 - 10]
Published in European Respiratory Journal. 2009, vol. 34, no. 2, p. 332-339
Abstract Systemic inflammation may mediate the association between chronic obstructive pulmonary disease (COPD) and extrapulmonary comorbidities. We measured high-sensitivity C-reactive protein (hs-CRP) in COPD and quantified the effect modification by body weight change and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and >14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) decline and body weight gain. Subjects with fast FEV(1) decline and weight gain (>14%) had higher hs-CRP (2.0 mg L(-1) for females versus 1.6 mg L(-1) for males). After adjustment for age, smoking, physical activity, hormonal therapy and diabetes, elevated hs-CRP (>3 mg) was found to be more likely in subjects with fast FEV(1) decline (OR(males) 1.38, OR(females) 1.42) and in those with weight gain >14% (OR(males) 2.04, OR(females) 4.51). The association of weight gain and fast FEV(1) decline predicts a higher level of systemic inflammation. Since the effect of weight gain on systemic inflammation is larger in females than in males, weight gain may be a risk factor for extrapulmonary comorbidities in females with COPD.
Keywords AdultAir PollutantsBody WeightC-Reactive Protein/metabolismCohort StudiesFemaleForced Expiratory VolumeHumans*InflammationMaleMiddle AgedPulmonary Disease, Chronic Obstructive/*complications/*diagnosis/physiopathologyRisk FactorsSex FactorsSmoking*Weight Gain
PMID: 19251780
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://erj.ersjournals.com/content/34/2/332.full.pdf
Research groups Groupe Jean-Michel Gaspoz (23)
L'épithélium respiratoire (852)
Monitoring du programme d'études et de formation pré-graduée de médecine (877)
Pneumologie Clinique (576)
(ISO format)
BRIDEVAUX, Pierre-Olivier et al. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. In: European Respiratory Journal, 2009, vol. 34, n° 2, p. 332-339. doi: 10.1183/09031936.00162608 https://archive-ouverte.unige.ch/unige:19707

505 hits

0 download


Deposited on : 2012-04-23

Export document
Format :
Citation style :