Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2

Bridevaux, Pierre-Olivier; Gerbase, Margaret; Schindler, C.; Dietrich, D Felber; Curjuric, I.; Dratva, J.; Ackermann-Liebrich, Ursula; Probst-Hensch, N. M.; Gaspoz, Jean-Michel; Rochat, Thierry

doi:10.1183/09031936.00162608

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Title		Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2
Authors		Bridevaux, Pierre-Olivier Gerbase, Margaret Schindler, C. Dietrich, D Felber Curjuric, I. Dratva, J. Ackermann-Liebrich, Ursula Probst-Hensch, N. M. Gaspoz, Jean-Michel Rochat, Thierry show all authors [1 - 10]
Published in		European Respiratory Journal. 2009, vol. 34, no. 2, p. 332-339
Abstract		Systemic inflammation may mediate the association between chronic obstructive pulmonary disease (COPD) and extrapulmonary comorbidities. We measured high-sensitivity C-reactive protein (hs-CRP) in COPD and quantified the effect modification by body weight change and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and >14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) decline and body weight gain. Subjects with fast FEV(1) decline and weight gain (>14%) had higher hs-CRP (2.0 mg L(-1) for females versus 1.6 mg L(-1) for males). After adjustment for age, smoking, physical activity, hormonal therapy and diabetes, elevated hs-CRP (>3 mg) was found to be more likely in subjects with fast FEV(1) decline (OR(males) 1.38, OR(females) 1.42) and in those with weight gain >14% (OR(males) 2.04, OR(females) 4.51). The association of weight gain and fast FEV(1) decline predicts a higher level of systemic inflammation. Since the effect of weight gain on systemic inflammation is larger in females than in males, weight gain may be a risk factor for extrapulmonary comorbidities in females with COPD.
Keywords		Adult — Air Pollutants — Body Weight — C-Reactive Protein/metabolism — Cohort Studies — Female — Forced Expiratory Volume — Humans — Inflammation — Male — Middle Aged — Pulmonary Disease, Chronic Obstructive/complications/diagnosis/physiopathology — Risk Factors — Sex Factors — Smoking — Weight Gain
Identifiers		DOI: 10.1183/09031936.00162608 PMID: 19251780
Full text		Article - Limited access to UNIGE Other version: http://erj.ersjournals.com/content/34/2/332.full.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires
Research groups		Groupe Jean-Michel Gaspoz (23) L'épithélium respiratoire (852) Monitoring du programme d'études et de formation pré-graduée de médecine (877) Pneumologie Clinique (576)
Citation (ISO format)		BRIDEVAUX, Pierre-Olivier et al. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. In: European Respiratory Journal, 2009, vol. 34, n° 2, p. 332-339. doi: 10.1183/09031936.00162608 https://archive-ouverte.unige.ch/unige:19707