

Other version: http://erj.ersjournals.com/content/34/2/332.full.pdf
![]() |
Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2 |
|
Authors | ![]() | |
Published in | European Respiratory Journal. 2009, vol. 34, no. 2, p. 332-339 | |
Abstract | Systemic inflammation may mediate the association between chronic obstructive pulmonary disease (COPD) and extrapulmonary comorbidities. We measured high-sensitivity C-reactive protein (hs-CRP) in COPD and quantified the effect modification by body weight change and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and >14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) decline and body weight gain. Subjects with fast FEV(1) decline and weight gain (>14%) had higher hs-CRP (2.0 mg L(-1) for females versus 1.6 mg L(-1) for males). After adjustment for age, smoking, physical activity, hormonal therapy and diabetes, elevated hs-CRP (>3 mg) was found to be more likely in subjects with fast FEV(1) decline (OR(males) 1.38, OR(females) 1.42) and in those with weight gain >14% (OR(males) 2.04, OR(females) 4.51). The association of weight gain and fast FEV(1) decline predicts a higher level of systemic inflammation. Since the effect of weight gain on systemic inflammation is larger in females than in males, weight gain may be a risk factor for extrapulmonary comorbidities in females with COPD. | |
Keywords | Adult — Air Pollutants — Body Weight — C-Reactive Protein/metabolism — Cohort Studies — Female — Forced Expiratory Volume — Humans — *Inflammation — Male — Middle Aged — Pulmonary Disease, Chronic Obstructive/*complications/*diagnosis/physiopathology — Risk Factors — Sex Factors — Smoking — *Weight Gain | |
Identifiers | PMID: 19251780 | |
Full text |
![]() ![]() Other version: http://erj.ersjournals.com/content/34/2/332.full.pdf |
|
Structures | ||
Research groups | Groupe Jean-Michel Gaspoz (23) L'épithélium respiratoire (852) Monitoring du programme d'études et de formation pré-graduée de médecine (877) Pneumologie Clinique (576) | |
Citation (ISO format) | BRIDEVAUX, Pierre-Olivier et al. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. In: European Respiratory Journal, 2009, vol. 34, n° 2, p. 332-339. doi: 10.1183/09031936.00162608 https://archive-ouverte.unige.ch/unige:19707 |