en
Scientific article
English

Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2

Published inThe European respiratory journal, vol. 34, no. 2, p. 332-339
Publication date2009
Abstract

Systemic inflammation may mediate the association between chronic obstructive pulmonary disease (COPD) and extrapulmonary comorbidities. We measured high-sensitivity C-reactive protein (hs-CRP) in COPD and quantified the effect modification by body weight change and sex. Using data from the Swiss study on Air Pollution and Lung Diseases in Adults (SAPALDIA; n = 5,479) with measurements of forced expiratory volume in 1 s (FEV(1)), body weight and hs-CRP, we examined the association of hs-CRP and categories of body weight change (lost weight and weight gained 0-5%, 5-9%, 9-14% and >14%) with fast FEV(1) decline. hs-CRP was elevated both in association with fast FEV(1) decline and body weight gain. Subjects with fast FEV(1) decline and weight gain (>14%) had higher hs-CRP (2.0 mg L(-1) for females versus 1.6 mg L(-1) for males). After adjustment for age, smoking, physical activity, hormonal therapy and diabetes, elevated hs-CRP (>3 mg) was found to be more likely in subjects with fast FEV(1) decline (OR(males) 1.38, OR(females) 1.42) and in those with weight gain >14% (OR(males) 2.04, OR(females) 4.51). The association of weight gain and fast FEV(1) decline predicts a higher level of systemic inflammation. Since the effect of weight gain on systemic inflammation is larger in females than in males, weight gain may be a risk factor for extrapulmonary comorbidities in females with COPD.

Keywords
  • Adult
  • Air Pollutants
  • Body Weight
  • C-Reactive Protein/metabolism
  • Cohort Studies
  • Female
  • Forced Expiratory Volume
  • Humans
  • *Inflammation
  • Male
  • Middle Aged
  • Pulmonary Disease, Chronic Obstructive/*complications/*diagnosis/physiopathology
  • Risk Factors
  • Sex Factors
  • Smoking
  • *Weight Gain
Citation (ISO format)
BRIDEVAUX, Pierre-Olivier et al. Sex-specific effect of body weight gain on systemic inflammation in subjects with COPD: results from the SAPALDIA cohort study 2. In: The European respiratory journal, 2009, vol. 34, n° 2, p. 332–339. doi: 10.1183/09031936.00162608
Main files (1)
Article
accessLevelRestricted
Identifiers
ISSN of the journal0903-1936
564views
0downloads

Technical informations

Creation04/23/2012 1:23:02 PM
First validation04/23/2012 1:23:02 PM
Update time03/14/2023 5:24:16 PM
Status update03/14/2023 5:24:15 PM
Last indexation02/12/2024 7:56:26 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack