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Sex differences in symptom patterns of recurrent major depression in siblings

Authors
Moskvina, Valentina
Farmer, Anne
Jones, Ian Richard
Brewster, Shyama
Gill, Michael
Jones, Lisa Anne
Maier, Wolfgang
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Published in Depression and Anxiety. 2008, vol. 25, no. 6, p. 527-534
Abstract The objectives of this study were to examine sex differences in depressive symptom patterns in 475 sib pairs with well-defined recurrent major depression and to test the hypotheses that (a) symptom patterns show higher intraclass correlations within same sex sib pairs versus mixed sex sib pairs; and (b) symptoms more associated with women, e.g. atypical depressive and anxiety symptoms, account for differences between male and female siblings within the same family. A total of 878 individuals, with a past history of at least two depressive episodes, were interviewed using the Schedules for Clinical Assessment in Neuropsychiatry interview and diagnosed according to DSM-IV using a computerized scoring program (CATEGO5). Intraclass correlations were compared between mixed and same sex sibs, and a conditional regression analysis in mixed sex sib pairs was performed to test whether specific symptoms account for differences between male and female siblings within the same family. Women showed a significantly earlier onset of depression compared with men (23.0 years, SD=10.6 versus 25.5, SD=12.5 years, P=0.0004), and a significantly greater frequency of several aspects of depressed mood was found in women compared with men, including atypical depressive features of fatiguability, appetite gain, weight gain and hypersomnia. Discordant sib-pair data analyses revealed five symptoms that accounted for the sex differences between siblings (P=.000035): phobia (exp(B)=2.04, P=0.017), hypersomnia (exp(B)=1.37, P=0.055), appetite loss (exp(B)=1.38, P=0.004) and appetite gain (exp(B)=2.19, P<0.001). Sex significantly modifies clinical features of depression and an earlier onset of depression and atypical depressive symptoms occur more frequently in women.
Keywords AdolescentAdultAge of OnsetAgedAged, 80 and overAnxiety Disorders/diagnosis/genetics/psychologyComorbidityDepressive Disorder, Major/diagnosis/genetics/psychologyFemaleHumansMaleMiddle AgedPersonality Assessment/statistics & numerical dataRecurrenceSex FactorsSiblings/psychologyStatistics as Topic
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PMID: 17935211
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MOSKVINA, Valentina et al. Sex differences in symptom patterns of recurrent major depression in siblings. In: Depression and Anxiety, 2008, vol. 25, n° 6, p. 527-534. https://archive-ouverte.unige.ch/unige:1968

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Deposited on : 2009-06-11

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