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Title

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Authors
Benjamin, Emelia J.
Rice, Kenneth M.
Arking, Dan E.
Pfeufer, Arne
van Noord, C.
Smith, A. V.
Schnabel, R. B.
Bis, J. C.
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Published in Nature Genetics. 2009, vol. 41, no. 8, p. 879-881
Abstract We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).
Keywords Atrial Fibrillation/*geneticsChromosomes, Human, Pair 16/geneticsEuropean Continental Ancestry Group/*genetics*Genetic Predisposition to DiseaseGenome-Wide Association StudyHomeodomain Proteins/*geneticsHumansMeta-Analysis as TopicMutation/*geneticsPolymorphism, Single Nucleotide/geneticsReproducibility of Results
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PMID: 19597492
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Research group Traits génétiques complexes (901)
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BENJAMIN, Emelia J. et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. In: Nature Genetics, 2009, vol. 41, n° 8, p. 879-881. https://archive-ouverte.unige.ch/unige:19676

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Deposited on : 2012-04-23

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