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Scientific article
English

Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry

Published inNature genetics, vol. 41, no. 8, p. 879-881
Publication date2009
Abstract

We conducted meta-analyses of genome-wide association studies for atrial fibrillation (AF) in participants from five community-based cohorts. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). We replicated this association in an independent cohort from the German AF Network (odds ratio = 1.44; P = 1.6 x 10(-11); combined RR = 1.25; combined P = 1.8 x 10(-15)).

Keywords
  • Atrial Fibrillation/*genetics
  • Chromosomes, Human, Pair 16/genetics
  • European Continental Ancestry Group/*genetics
  • *Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Homeodomain Proteins/*genetics
  • Humans
  • Meta-Analysis as Topic
  • Mutation/*genetics
  • Polymorphism, Single Nucleotide/genetics
  • Reproducibility of Results
Citation (ISO format)
BENJAMIN, Emelia J., EHRET, Georg Benedikt. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. In: Nature genetics, 2009, vol. 41, n° 8, p. 879–881. doi: 10.1038/ng.416
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ISSN of the journal1061-4036
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