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Scientific article
English

Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

Contributors

Benhamou, P. Y.; Milliat-Guittard, L.; Wojtusciszyn, Anne; Kessler, L.; Toso, Christian; Baertschiger, Reto Marc; Debaty, I.; Badet, L.; Penfornis, A.; Thivolet, C.; Renard, E.; Bayle, F.; Morel, Philippe; Morelon, E.; Colin, C.; Berney, Thierry

Published in

Diabetic medicine, vol. 26, no. 6, p. 617-621

Publication date

2009

Abstract

BACKGROUND: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. METHODS: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). RESULTS: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. CONCLUSION: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.

Keywords

  • Clinical Trials as Topic
  • Diabetes Mellitus, Type 1/*surgery
  • Female
  • Humans
  • *Islets of Langerhans Transplantation
  • Male
  • Middle Aged
  • *Quality of Life
  • Treatment Outcome

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BENHAMOU, P. Y. et al. Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials. In: Diabetic medicine, 2009, vol. 26, n° 6, p. 617–621. doi: 10.1111/j.1464-5491.2009.02731.x

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Additional URL for this publication

http://onlinelibrary.wiley.com/store/10.1111/j.1464-5491.2009.02731.x/asset/j.1464-5491.2009.02731.x.pdf?v=1&t=gzr4s8ha&s=8f212ae672652b5e242683787817afaa4811f94d

Journal ISSN

0742-3071
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Technical informations

Creation

23/04/2012 13:22:53

First validation

23/04/2012 13:22:53

Update

14/10/2025 00:16:11

Status update

14/03/2023 17:24:01

Last indexation

04/02/2026 14:46:11
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