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Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials

Benhamou, P. Y.
Milliat-Guittard, L.
Kessler, L.
Debaty, I.
Badet, L.
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Published in Diabetic Medicine. 2009, vol. 26, no. 6, p. 617-621
Abstract BACKGROUND: Rigorous assessment of health-related quality of life (HRQL) is mandatory to establish the benefits of islet transplantation. METHODS: The 36-Item Short Form Health Survey (SF-36) and the Diabetes Quality of Life (DQOL) scales were completed by patients included in an Islet Transplantation Alone (ITA) trial (n = 10) and an Islet After Kidney (IAK) trial (n = 10). RESULTS: The two populations differed by HRQL scores at baseline, with poorer scores in ITA patients. SF-36 scores for physical limitations, bodily pain, general health perception, social functioning, and health transition improved significantly in ITA patients 6 and 12 months post transplantation. The DQOL global score was significantly improved at 6 months and remained so at 12 months, because of a significant improvement in the dimensions of satisfaction and impact of diabetes. No improvement was observed in the IAK patients. CONCLUSION: HRQL assessment may help in the selection of candidates with brittle diabetes for islet transplantation.
Keywords Clinical Trials as TopicDiabetes Mellitus, Type 1/*surgeryFemaleHumans*Islets of Langerhans TransplantationMaleMiddle Aged*Quality of LifeTreatment Outcome
PMID: 19538237
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Research groups Chirurgie viscérale (104)
La transplantation d'îlots de Langerhans (623)
Transplantation et hépatologie (905)
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BENHAMOU, P. Y. et al. Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials. In: Diabetic Medicine, 2009, vol. 26, n° 6, p. 617-621. doi: 10.1111/j.1464-5491.2009.02731.x https://archive-ouverte.unige.ch/unige:19675

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Deposited on : 2012-04-23

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