• Home
  1. Home
  2. Effect of labetalol on adrenoceptors in the isolated perfused rat mesentery
Scientific article
OA Policy
English

Effect of labetalol on adrenoceptors in the isolated perfused rat mesentery

Contributors

Gulati, N.; Huggel, Hansjorg; Gulati, O.P.

Published in

Archives internationales de pharmacodynamie et de thérapie, vol. 246, no. 2, p. 251-256

Publication date

1980-08

Abstract

Isolated perfused rat mesentery has been used to define alpha- and beta-adrenoceptors. Norepinephrine was used as a reference substance to induce vasoconstrictor responses (increase in perfusion pressure). Log-dose response curves were obtained in the dose range between 0.3-10 mug. Labetalol, a known competitive inhibitor of both alpha- and beta-adrenoceptors, when administered as a single bolus injection (3 mug) initially induced predominant alpha-blockade lasting upto 75 min followed by potentiation of the vasoconstrictor responses to norepinephrine used at multiple dose levels. This potentiation was maximum between 150-195 min after injection of labetalol. This potentiating effect of labetalol observed in the later phase of the experiment might be related to its inhibitory mechanism of neuronal uptake.

Keywords

  • Animals
  • Ethanolamines / pharmacology
  • In Vitro Techniques
  • Labetalol / pharmacology
  • Norepinephrine / pharmacology
  • Phentolamine / pharmacology
  • Rats
  • Receptors, Adrenergic / drug effects
  • Splanchnic Circulation / drug effects
  • Vasoconstriction / drug effects

Note

Travaux du Département de biologie animale ; vol. 24, no 801

UNIGE affiliation entities

Citation (ISO format)

GULATI, N., HUGGEL, Hansjorg, GULATI, O.P. Effect of labetalol on adrenoceptors in the isolated perfused rat mesentery. In: Archives internationales de pharmacodynamie et de thérapie, 1980, vol. 246, n° 2, p. 251–256.

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0003-9780
4views
8downloads

Technical informations

Creation

21/10/2026 10:13:02

First validation

22/10/2026 10:59:55

Update

22/10/2026 10:59:55

Status update

22/10/2026 10:59:55

Last indexation

22/10/2026 10:59:56
All rights reserved by Archive ouverte UNIGE and the University of Geneva
OpenAIRE Indexed & Validated