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Diagnosis and treatment of acquired aplastic anemia

Bacigalupo, Andrea
Published in Hematology Oncology Clinics of North America. 2009, vol. 23, no. 2, p. 159-170
Abstract Acquired severe aplastic anemia can be treated successfully with either immunosuppressive therapy or bone marrow transplantation. Although immunosuppressive therapy can be readily administered to all patients, it is not a curative approach and is associated with a higher risk of clonal evolution than is transplantation, which yields rapid and long-lasting hematologic remission. This article reviews the key diagnostic and prognostic factors that influence the choice of therapy in patients with acquired aplastic anemia.
Keywords Age FactorsAnemia, Aplastic/*diagnosis/drug therapy/*therapyAnimalsAntilymphocyte Serum/*therapeutic useBone Marrow Transplantation/*immunology/mortalityCyclosporine/*therapeutic useFemaleFetal Blood/transplantationHumansImmunosuppressive Agents/*therapeutic useIntercellular Signaling Peptides and Proteins/*therapeutic useMalePregnancyPrognosis
PMID: 19327577
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BACIGALUPO, Andrea, PASSWEG, Jakob. Diagnosis and treatment of acquired aplastic anemia. In: Hematology Oncology Clinics of North America, 2009, vol. 23, n° 2, p. 159-170. doi: 10.1016/j.hoc.2009.01.005 https://archive-ouverte.unige.ch/unige:19655

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Deposited on : 2012-04-23

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