Diagnosis and treatment of acquired aplastic anemia

Bacigalupo, Andrea; Passweg, Jakob

doi:10.1016/j.hoc.2009.01.005

Scientific article

Review

English

Diagnosis and treatment of acquired aplastic anemia

Contributors

Bacigalupo, Andrea; Passweg, Jakob

Published in

Hematology/oncology clinics of North America, vol. 23, no. 2, p. 159-170

Publication date

2009

Abstract

Acquired severe aplastic anemia can be treated successfully with either immunosuppressive therapy or bone marrow transplantation. Although immunosuppressive therapy can be readily administered to all patients, it is not a curative approach and is associated with a higher risk of clonal evolution than is transplantation, which yields rapid and long-lasting hematologic remission. This article reviews the key diagnostic and prognostic factors that influence the choice of therapy in patients with acquired aplastic anemia.

Keywords

Age Factors
Anemia, Aplastic/*diagnosis/drug therapy/*therapy
Animals
Antilymphocyte Serum/*therapeutic use
Bone Marrow Transplantation/*immunology/mortality
Cyclosporine/*therapeutic use
Female
Fetal Blood/transplantation
Humans
Immunosuppressive Agents/*therapeutic use
Intercellular Signaling Peptides and Proteins/*therapeutic use
Male
Pregnancy
Prognosis

UNIGE affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

BACIGALUPO, Andrea, PASSWEG, Jakob. Diagnosis and treatment of acquired aplastic anemia. In: Hematology/oncology clinics of North America, 2009, vol. 23, n° 2, p. 159–170. doi: 10.1016/j.hoc.2009.01.005

Article

Identifiers

PID : unige:19655
DOI : 10.1016/j.hoc.2009.01.005
PMID : 19327577

Additional URL for this publication

http://www.mdconsult.com/das/article/body/323154182-2/jorg=journal%26source=%26sp=21972292%26sid=0/N/692038/s0889858809000069.pdf?issn=0889-8588

Journal ISSN

0889-8588

627views

0downloads

Creation

23/04/2012 13:22:47

First validation

23/04/2012 13:22:47

Update

14/03/2023 17:23:52

Status update

14/03/2023 17:23:52

Last indexation

29/10/2024 19:27:05

Diagnosis and treatment of acquired aplastic anemia

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Additional URL for this publication

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation