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Scientific article
English

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Published inLeukemia, vol. 22, no. 2, p. 400-405
Publication date2008
Abstract

To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.

Keywords
  • Aged
  • Aged, 80 and over
  • B-Lymphocytes/*pathology
  • Central Nervous System Neoplasms/*genetics/pathology
  • Female
  • *Gene Expression Profiling
  • Germinal Center/*pathology
  • Humans
  • Immunocompetence
  • Lymphoma/*genetics/pathology
  • Lymphoma, Large B-Cell, Diffuse/genetics/pathology
  • Male
  • Microarray Analysis
  • Middle Aged
Citation (ISO format)
MONTESINOS-RONGEN, M. et al. Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. In: Leukemia, 2008, vol. 22, n° 2, p. 400–405. doi: 10.1038/sj.leu.2405019
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ISSN of the journal0887-6924
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