UNIGE document Scientific Article
previous document  unige:19627  next document
add to browser collection
Title

Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell

Authors
Montesinos-Rongen, M.
Brunn, A.
Bentink, S.
Basso, K.
Lim, W. K.
Klapper, W.
Reifenberger, G.
show hidden authors show all authors [1 - 14]
Published in Leukemia. 2008, vol. 22, no. 2, p. 400-405
Abstract To characterize the molecular origin of primary lymphomas of the central nervous system (PCNSL), 21 PCNSLs of immunocompetent patients were investigated by microarray-based gene expression profiling. Comparison of the transcriptional profile of PCNSL with various normal and neoplastic B-cell subsets demonstrated PCNSL (i) to display gene expression patterns most closely related to late germinal center B cells, (ii) to display a gene expression profile similar to systemic diffuse large B-cell lymphomas (DLBCLs) and (iii) to be in part assigned to the activated B-cell-like (ABC) or the germinal center B-cell-like (GCB) subtype of DLBCL.
Keywords AgedAged, 80 and overB-Lymphocytes/*pathologyCentral Nervous System Neoplasms/*genetics/pathologyFemale*Gene Expression ProfilingGerminal Center/*pathologyHumansImmunocompetenceLymphoma/*genetics/pathologyLymphoma, Large B-Cell, Diffuse/genetics/pathologyMaleMicroarray AnalysisMiddle Aged
Identifiers
PMID: 17989719
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://www.nature.com/leu/journal/v22/n2/pdf/2405019a.pdf
Structures
Research group Groupe Schaller Karl-Lothard (neurochirurgie) (851)
Citation
(ISO format)
MONTESINOS-RONGEN, M. et al. Gene expression profiling suggests primary central nervous system lymphomas to be derived from a late germinal center B cell. In: Leukemia, 2008, vol. 22, n° 2, p. 400-405. https://archive-ouverte.unige.ch/unige:19627

170 hits

0 download

Update

Deposited on : 2012-04-23

Export document
Format :
Citation style :