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Title

Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature

Authors
Pass, Amy Kun
Rushton, Jennifer R.
Kearney, Debra L.
Hastings, Caroline A.
Margolin, Judith F.
Published in Journal of Pediatric Hematology / Oncology. 2008, vol. 30, no. 12, p. 976-980
Abstract This is the first description in which the diagnosis of vanishing bile duct syndrome (VBDS) preceded the diagnosis of Hodgkin disease (HD) by several months, and for which patients received modifications to modern MOPP-ABV chemotherapy with successful clinical remission. VBDS is an uncommon form of liver disease manifested by severe cholestasis and progressive liver failure. We report 2 cases of stage IIIB pediatric HD and VBDS. Because VBDS is progressive and the only curative treatment is liver transplant, it is imperative to recognize that children with VBDS may also have concurrent HD.
Keywords Antineoplastic Combined Chemotherapy Protocols/*therapeutic useBleomycin/therapeutic useChildCholestasis/*diagnosis/drug therapyCombined Modality TherapyDoxorubicin/therapeutic useHodgkin Disease/*diagnosis/drug therapyHumansMaleMechlorethamine/therapeutic usePrednisone/therapeutic useProcarbazine/therapeutic useRadiotherapy DosageRemission InductionSyndromeTreatment OutcomeVinblastine/therapeutic useVincristine/therapeutic use
Identifiers
PMID: 19131796
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Article - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Développement du tube digestif chez les vertébrés (900)
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PASS, Amy Kun et al. Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature. In: Journal of Pediatric Hematology / Oncology, 2008, vol. 30, n° 12, p. 976-980. https://archive-ouverte.unige.ch/unige:19626

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Deposited on : 2012-04-23

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