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Title

Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)

Authors
Zehnder, Aina
Fisch, Urs
Hirt, Andreas
Niggli, Felix K.
Simon, Arne
Schlapbach, Luregn J.
Ammann, Roland A.
Published in Pediatric Blood and Cancer. 2009, vol. 53, no. 1, p. 53-57
Abstract BACKGROUND: Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are key components of the lectin pathway of complement activation. Their serum concentrations show a wide interindividual variability. This study investigated whether the concentration of MBL and MASP-2 is associated with prognosis in pediatric patients with cancer. METHODS: In this retrospective multicenter study, MBL and MASP-2 were measured by commercially available ELISA in frozen remnants of serum taken at diagnosis. Associations of overall survival (OS) and event-free survival (EFS) with MBL and MASP-2 were assessed by multivariate Cox regression accounting for prognostically relevant clinical variables. RESULTS: In the 372 patients studied, median serum concentration of MBL was 2,808 microg/L (range, 2-10,060) and 391 microg/L (46-2,771) for MASP-2. The estimated 4-year EFS was 0.60 (OS, 0.78). In the entire, heterogeneous sample, MBL and MASP-2 were not significantly associated with OS or EFS. In patients with hematologic malignancies, however, higher MASP-2 was associated with better EFS in a significant and clinically relevant way (hazard ratio per tenfold increase (HR), 0.22; 95% CI, 0.09-0.54; P = 0.001). This was due to patients with lymphoma (HR, 0.11; 95% CI, 0.03-0.47; P = 0.003), but less for those with acute leukemia (HR, 0.35; 95% CI, 0.11-1.15; P = 0.083). CONCLUSION: In this study, higher MASP-2 was associated with better EFS in pediatric patients with hematologic malignancies, especially lymphoma. Whether MASP-2 is an independent prognostic factor affecting risk stratification and anticancer therapy needs to be assessed in prospective, disease-specific studies.
Keywords ChildChild, PreschoolCohort StudiesDisease-Free SurvivalFemaleHematologic Neoplasms/*blood/*mortalityHumansMaleMannose-Binding Lectin/*bloodMannose-Binding Protein-Associated Serine Proteases/*metabolismPrognosisRetrospective StudiesSurvival RateTumor Markers, Biological/*blood
Identifiers
PMID: 19343776
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Research group Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
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ZEHNDER, Aina et al. Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2). In: Pediatric Blood and Cancer, 2009, vol. 53, n° 1, p. 53-57. https://archive-ouverte.unige.ch/unige:19612

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Deposited on : 2012-04-23

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