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Other version: http://onlinelibrary.wiley.com/store/10.1002/pbc.22028/asset/22028_ftp.pdf?v=1&t=gzs8pjyi&s=94eb397c2d1253e09f6e9b392...
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)
|Published in||Pediatric Blood and Cancer. 2009, vol. 53, no. 1, p. 53-57|
|Abstract||BACKGROUND: Mannose-binding lectin (MBL) and MBL-associated serine protease-2 (MASP-2) are key components of the lectin pathway of complement activation. Their serum concentrations show a wide interindividual variability. This study investigated whether the concentration of MBL and MASP-2 is associated with prognosis in pediatric patients with cancer. METHODS: In this retrospective multicenter study, MBL and MASP-2 were measured by commercially available ELISA in frozen remnants of serum taken at diagnosis. Associations of overall survival (OS) and event-free survival (EFS) with MBL and MASP-2 were assessed by multivariate Cox regression accounting for prognostically relevant clinical variables. RESULTS: In the 372 patients studied, median serum concentration of MBL was 2,808 microg/L (range, 2-10,060) and 391 microg/L (46-2,771) for MASP-2. The estimated 4-year EFS was 0.60 (OS, 0.78). In the entire, heterogeneous sample, MBL and MASP-2 were not significantly associated with OS or EFS. In patients with hematologic malignancies, however, higher MASP-2 was associated with better EFS in a significant and clinically relevant way (hazard ratio per tenfold increase (HR), 0.22; 95% CI, 0.09-0.54; P = 0.001). This was due to patients with lymphoma (HR, 0.11; 95% CI, 0.03-0.47; P = 0.003), but less for those with acute leukemia (HR, 0.35; 95% CI, 0.11-1.15; P = 0.083). CONCLUSION: In this study, higher MASP-2 was associated with better EFS in pediatric patients with hematologic malignancies, especially lymphoma. Whether MASP-2 is an independent prognostic factor affecting risk stratification and anticancer therapy needs to be assessed in prospective, disease-specific studies.|
|Keywords||Child — Child, Preschool — Cohort Studies — Disease-Free Survival — Female — Hematologic Neoplasms/*blood/*mortality — Humans — Male — Mannose-Binding Lectin/*blood — Mannose-Binding Protein-Associated Serine Proteases/*metabolism — Prognosis — Retrospective Studies — Survival Rate — Tumor Markers, Biological/*blood|
|Research group||Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)|
|ZEHNDER, Aina et al. Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2). In: Pediatric Blood and Cancer, 2009, vol. 53, n° 1, p. 53-57. https://archive-ouverte.unige.ch/unige:19612|