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Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia

Wehrli, Lea A.
Braun, Julia
Buetti, Luisa Nobile
Hagleitner, Nicole
Hengartner, Heinz
Kuhne, Thomas
Luer, Sonja
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Published in Cancer Genetics and Cytogenetics. 2009, vol. 189, no. 1, p. 29-36
Abstract Karyotype analysis of acute lymphoblastic leukemia (ALL) at diagnosis has provided valuable prognostic markers for treatment stratification. However, reports of cytogenetic studies of relapsed ALL samples are limited. We compared the karyotypes from 436 nonselected B-cell precursor ALL patients at initial diagnosis and of 76 patients at first relapse. We noticed a relative increase of karyotypes that did not fall into the classic ALL cytogenetic subgroups (high hyperdiploidy, t(12;21), t(9;22), 11q23, t(1;19), <45 chromosomes) in a group of 29 patients at relapse (38%) compared to 130 patients at presentation (30%). Non-classical cytogenetic aberrations in these 29 patients were mostly found on chromosomes 1, 2, 7, 9, 13, 14, and 17. We also describe six rare reciprocal translocations, three of which involved 14q32. The most frequent abnormalities were found in 9p (12/29 cases) and were associated with a marked decrease in the duration of the second remission, but not of the probability of 10-year event-free survival after relapse treatment. From 29 patients with non-classical cytogenetic aberrations, only 8 (28%) had been stratified to a high risk-arm on the first treatment protocol, suggesting that this subgroup might benefit from the identification of new prognostic markers in future studies.
Keywords Acute DiseaseAdolescentChildChild, PreschoolChromosome AberrationsFemaleHumansInfantKaryotypingMalePrecursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/prevention & controlRecurrenceTranslocation, GeneticTreatment Outcome
PMID: 19167609
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Research group Groupe Ozsahin Ayse Hulya (onco-hémato pédiatrie) (889)
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WEHRLI, Lea A. et al. Non-classical karyotypic features in relapsed childhood B-cell precursor acute lymphoblastic leukemia. In: Cancer Genetics and Cytogenetics, 2009, vol. 189, n° 1, p. 29-36. doi: 10.1016/j.cancergencyto.2008.10.002 https://archive-ouverte.unige.ch/unige:19610

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Deposited on : 2012-04-23

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