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SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

Azim, Eiman
Fame, Ryann M.
Macklis, Jeffrey D.
Published in Nature neuroscience. 2009, vol. 12, no. 10, p. 1238-1247
Abstract The neuronal diversity of the CNS emerges largely from controlled spatial and temporal segregation of cell type-specific molecular regulators. We found that the transcription factor SOX6 controls the molecular segregation of dorsal (pallial) from ventral (subpallial) telencephalic progenitors and the differentiation of cortical interneurons, regulating forebrain progenitor and interneuron heterogeneity. During corticogenesis in mice, SOX6 and SOX5 were largely mutually exclusively expressed in pallial and subpallial progenitors, respectively, and remained mutually exclusive in a reverse pattern in postmitotic neuronal progeny. Loss of SOX6 from pallial progenitors caused their inappropriate expression of normally subpallium-restricted developmental controls, conferring mixed dorsal-ventral identity. In postmitotic cortical interneurons, loss of SOX6 disrupted the differentiation and diversity of cortical interneuron subtypes, analogous to SOX5 control over cortical projection neuron development. These data indicate that SOX6 is a central regulator of both progenitor and cortical interneuron diversity during neocortical development.
Keywords AnimalsAnimals, NewbornBasic Helix-Loop-Helix Transcription Factors/deficiencyBody PatterningBromodeoxyuridine/metabolismCell Count/methodsCell DifferentiationCell MovementElectroporation/methodsEmbryo, MammalianEmbryonic Stem Cells/*physiologyGene Expression Regulation, Developmental/genetics/*physiologyGlutamate Decarboxylase/geneticsGreen Fluorescent Proteins/geneticsInterneurons/classification/*physiologyMiceMice, Inbred C57BLMice, Transgenic*Neocortex/cytology/embryology/growth & developmentNerve Tissue Proteins/deficiency/metabolism*NeurogenesisProliferating Cell Nuclear Antigen/metabolismSOXD Transcription Factors/deficiency/*physiology
PMID: 19657336
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Research group Neurobiologie développementale et plasticité (880)
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AZIM, Eiman et al. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. In: Nature neuroscience, 2009, vol. 12, n° 10, p. 1238-1247. doi: 10.1038/nn.2387 https://archive-ouverte.unige.ch/unige:19601

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Deposited on : 2012-04-23

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