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Scientific article
English

SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development

Contributors

Azim, Eiman; Jabaudon, Denis; Fame, Ryann M.; Macklis, Jeffrey D.

Published in

Nature neuroscience, vol. 12, no. 10, p. 1238-1247

Publication date

2009

Abstract

The neuronal diversity of the CNS emerges largely from controlled spatial and temporal segregation of cell type-specific molecular regulators. We found that the transcription factor SOX6 controls the molecular segregation of dorsal (pallial) from ventral (subpallial) telencephalic progenitors and the differentiation of cortical interneurons, regulating forebrain progenitor and interneuron heterogeneity. During corticogenesis in mice, SOX6 and SOX5 were largely mutually exclusively expressed in pallial and subpallial progenitors, respectively, and remained mutually exclusive in a reverse pattern in postmitotic neuronal progeny. Loss of SOX6 from pallial progenitors caused their inappropriate expression of normally subpallium-restricted developmental controls, conferring mixed dorsal-ventral identity. In postmitotic cortical interneurons, loss of SOX6 disrupted the differentiation and diversity of cortical interneuron subtypes, analogous to SOX5 control over cortical projection neuron development. These data indicate that SOX6 is a central regulator of both progenitor and cortical interneuron diversity during neocortical development.

Keywords

  • Animals
  • Animals, Newborn
  • Basic Helix-Loop-Helix Transcription Factors/deficiency
  • Body Patterning
  • Bromodeoxyuridine/metabolism
  • Cell Count/methods
  • Cell Differentiation
  • Cell Movement
  • Electroporation/methods
  • Embryo, Mammalian
  • Embryonic Stem Cells/*physiology
  • Gene Expression Regulation, Developmental/genetics/*physiology
  • Glutamate Decarboxylase/genetics
  • Green Fluorescent Proteins/genetics
  • Interneurons/classification/*physiology
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • *Neocortex/cytology/embryology/growth & development
  • Nerve Tissue Proteins/deficiency/metabolism
  • *Neurogenesis
  • Proliferating Cell Nuclear Antigen/metabolism
  • SOXD Transcription Factors/deficiency/*physiology

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

AZIM, Eiman et al. SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development. In: Nature neuroscience, 2009, vol. 12, n° 10, p. 1238–1247. doi: 10.1038/nn.2387

Main files (1)

Article

Identifiers

Additional URL for this publication

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903203/pdf/nihms134256.pdf

Journal ISSN

1097-6256
637views
2downloads

Technical informations

Creation

23/04/2012 13:22:30

First validation

23/04/2012 13:22:30

Update

14/03/2023 17:23:24

Status update

14/03/2023 17:23:24

Last indexation

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