Scientific article
OA Policy
English

Human cellular restriction factors that target HIV-1 replication

Published inBMC medicine, vol. 7, 48
Publication date2009
Abstract

Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.

Keywords
  • Antigens, CD/physiology
  • Carrier Proteins/physiology
  • Cyclophilin A/physiology
  • Cytidine Deaminase/physiology
  • GPI-Linked Proteins
  • HIV Infections/*immunology/virology
  • HIV-1/*immunology
  • Humans
  • *Immunity, Innate
  • Membrane Glycoproteins/physiology
  • MicroRNAs/physiology
  • Virus Replication/*immunology
Citation (ISO format)
STREBEL, Klaus, LUBAN, Jeremy, JEANG, Kuan-Teh. Human cellular restriction factors that target HIV-1 replication. In: BMC medicine, 2009, vol. 7, p. 48. doi: 10.1186/1741-7015-7-48
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Identifiers
ISSN of the journal1741-7015
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