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Human cellular restriction factors that target HIV-1 replication

Strebel, Klaus
Jeang, Kuan-Teh
Published in BMC Medicine. 2009, vol. 7, 48
Abstract Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5alpha), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of these cellular restriction functions.
Keywords Antigens, CD/physiologyCarrier Proteins/physiologyCyclophilin A/physiologyCytidine Deaminase/physiologyGPI-Linked ProteinsHIV Infections/*immunology/virologyHIV-1/*immunologyHumans*Immunity, InnateMembrane Glycoproteins/physiologyMicroRNAs/physiologyVirus Replication/*immunology
PMID: 19758442
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Research group Réplication virale, pathogénèse et immunité (848)
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STREBEL, Klaus, LUBAN, Jeremy, JEANG, Kuan-Teh. Human cellular restriction factors that target HIV-1 replication. In: BMC Medicine, 2009, vol. 7, p. 48. doi: 10.1186/1741-7015-7-48 https://archive-ouverte.unige.ch/unige:19584

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Deposited on : 2012-04-23

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