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The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury

Published in Thrombosis and haemostasis. 2009, vol. 102, no. 2, p. 240-247
Abstract Acute myocardial infarction is the leading cause of morbidity and mortality in the adult population of developed and developing nations. Although the prompt restoration of antegrade blood flow in the infarct-related coronary artery is the mean therapy for improving survival, reperfusion itself may cause damage to ischaemic myocardial tissue. This event is well known as "reperfusion injury". Crucial mediators for cardiac damage in the reperfusion phases are oxidative stress, inflammation and leukocyte infiltration. Already approved and novel therapies might directly reduce these inflammatory processes. Treatments modulating chemokine secretion and activity should be considered as very promising approaches to reduce myocardial reperfusion injury.
Keywords Adrenergic beta-Antagonists/therapeutic useAdultAngiotensin-Converting Enzyme Inhibitors/therapeutic useAnimalsAnti-Inflammatory Agents/therapeutic useAnticoagulants/therapeutic useHumansHydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic useImmunosuppressive Agents/therapeutic useInflammation/physiopathology/prevention & controlInflammation Mediators/physiologyModels, CardiovascularMyocardial Infarction/drug therapy/physiopathology/therapyMyocardial Reperfusion Injury/physiopathology/*prevention & controlPlatelet Aggregation Inhibitors/therapeutic use
PMID: 19652874
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
Le rôle du système endocannabinoïde dans l'athérosclérose (882)
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STEFFENS, Sabine, MONTECUCCO, Fabrizio, MACH, François. The inflammatory response as a target to reduce myocardial ischaemia and reperfusion injury. In: Thrombosis and haemostasis, 2009, vol. 102, n° 2, p. 240-247. doi: 10.1160/TH08-12-0837 https://archive-ouverte.unige.ch/unige:19582

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Deposited on : 2012-04-23

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