Scientific article
Case report

Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma

Published inInternational journal of hematology, vol. 89, no. 5, p. 693-698
Publication date2009

We present the case of a 52-year-old man with a 2-month history of dyspnea, bilateral pleural effusion and cardiomegaly of rapid onset. A cardiac ultrasound showed pericardial effusion with infiltration of the infero-lateral cardiac wall, right auricle and aortic arch by a mass of unknown origin. Despite 1% blast cells in the peripheral blood, 2 bone marrow biopsies were negative for malignancy. Flow cytometry analysis of the blood and immunohistochemistry study of the pleural liquid showed a blast population of CD34+, CD33+, CD13+ and HLA-DR+ cells; a percutaneous cardiac biopsy showed CD34+ cells in the pericardium which led to the diagnosis of extramedullary acute myeloid leukemia (AML). The patient was treated with induction chemotherapy allowing remission, but unfortunately died of septic shock of fungal origin. This case illustrates a rare presentation of cardiac extramedullary AML.

  • Cardiomegaly
  • Fatal Outcome
  • Heart Neoplasms/*diagnosis/drug therapy
  • Humans
  • Immunophenotyping
  • Leukemia, Myeloid, Acute/*diagnosis/drug therapy
  • Male
  • Middle Aged
  • Pleural Effusion/pathology
  • Remission Induction
  • Sarcoma, Myeloid/*diagnosis/drug therapy
  • Shock, Septic
Citation (ISO format)
RIGAMONTI, Fabio et al. Atypical presentation of acute myeloid leukemia: cardiac myeloid sarcoma. In: International journal of hematology, 2009, vol. 89, n° 5, p. 693–698. doi: 10.1007/s12185-009-0313-6
ISSN of the journal0925-5710

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