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Effect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk

Published in Pharmacological Reports. 2009, vol. 61, no. 1, p. 13-21
Abstract The endocannabinoid system is a crucial player in the inflammatory processes underlying atherosclerosis. Recently, basic research studies and animal models have strongly supported the role of the endocannabinoid system not only in the regulation of classical cardiovascular risk factors (including lipid profile and glucose homeostasis), but also in the activation of immune cells and inflammatory mediators. Clinical trials investigating treatment with rimonabant (a selective antagonist of the cannabinoid type 1 receptor) have suggested a beneficial effect of this drug in the management of obesity. Further studies are needed to explore a possible use for rimonabant in treating type 2 diabetes and acute and chronic cardiovascular disease. Despite the slight increase in adverse events (mainly psychiatric), which has led to the recent withdrawal of rimonabant from the market, CB(1) receptor antagonism might represent a very promising therapeutic strategy to reduce the cardiovascular risk. In the present review, we focused on the most important experimental investigations into the role of the endocannabinoid system in atherosclerosis and cardiovascular risk.
Keywords AnimalsAtherosclerosis/etiology/physiopathology/prevention & controlCardiovascular Diseases/etiology/physiopathology/*prevention & controlClinical Trials as TopicDisease Models, AnimalEndocannabinoids/*metabolismHumansObesity/complications/drug therapyPiperidines/adverse effects/pharmacology/therapeutic usePyrazoles/adverse effects/pharmacology/therapeutic useReceptor, Cannabinoid, CB1/*antagonists & inhibitorsRisk Factors
PMID: 19307689
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Research groups Biologie du myocarde (22)
L'athérosclérose et ses complications cliniques (591)
Le rôle du système endocannabinoïde dans l'athérosclérose (882)
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MACH, François, MONTECUCCO, Fabrizio, STEFFENS, Sabine. Effect of blockage of the endocannabinoid system by CB(1) antagonism on cardiovascular risk. In: Pharmacological Reports, 2009, vol. 61, n° 1, p. 13-21. https://archive-ouverte.unige.ch/unige:19554

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Deposited on : 2012-04-23

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