Multimodal Whole Brain Imaging in Epilepsy (MOBILE) is a multimodal dataset from 30 drug-resistant focal epilepsy (DRFE) patients and 32 age-matched healthy controls, probing brain structure and function at multiple scales using invasive and non-invasive electrophysiology and imaging measures. In patients it assembles raw and processed data from: fluorodeoxyglucose positron emission tomography (18F-FDG-PET), simultaneous electroencephalography-magnetoencephalography (EEG-MEG), stereotactic-electroencephalography (SEEG) recordings of seizures, interictal awake resting state and sleep alongside post-implantation computed tomography (CT) scan with SEEG electrodes, high-resolution proton magnetic resonance imaging (MRI) at 3T and 7T, magnetic resonance spectroscopy imaging (MRSI) at 3T, and sodium MRI at 7T. Patients who had surgery also underwent a post-surgical 3T MRI. In control participants it assembles raw and processed data from: simultaneous EEG-MEG, high-resolution proton MRI at 3T and 7T, sodium MRI at 7T, phosphorous MRI at 7T, and simultaneous EEG and functional MRI acquisition (EEG-fMRI) at 7T. Data across these various modalities were acquired for each control participant whenever feasible. The 7T proton MRI protocol across the patients and controls includes anatomical T1 weighted (T1w) and T2 weighted (T2w), diffusion (dMRI), and resting state functional (rsfMRI) data. The 3T MRI proton protocol includes anatomical T1w, dMRI, and either MRSI for the patients or rsfMRI acquisitions for controls. The 3T post-surgical MRI proton protocol includes an anatomical T1w acquisition. The control cohort underwent additional 7T phosphorous imaging and simultaneous 7T EEG-fMRI. The 7T MOBILE database thus includes 3D quantitative information probing: 1. Ion homeostasis assessed by sodium concentrations (7T sodium MRI) 2. Metabolism assessed by glucose metabolic rate (18F-FDG-PET), N acetyl-aspartate (NAA), total creatine, myo-Inositol, and choline compounds concentrations (3T MRSI), ATP concentration (7T phosphorous MRSI) 3. Neuronal activity assessed by local field potentials (LFPs) and magnetic field recordings (SEEG, EEG-MEG) 4. Hemodynamic activity assessed by blood oxygen level dependent (BOLD) signal recording (3T and 7T rsfMRI), and simultaneous hemodynamic BOLD and neuronal activity (7T EEG-fMRI) 5. Structural integrity and organization assessed by structural imaging and tractography (T1w, T2w, and dMRI at 3T and 7T).