en
Scientific article
English

In situ detection of APRIL-rich niches for plasma-cell survival and their contribution to B-cell lymphoma development

Published inHistology and histopathology, vol. 24, no. 8, p. 1061-1066
Publication date2009
Abstract

A proliferation inducing ligand (APRIL) is one of the most recently cloned members of the tumor necrosis factor (TNF) family. Early experiments implicated a pathophysiological role for APRIL in the promotion of solid tumors. Later, identification of APRIL receptors on B lymphocytes indicated a physiological role for APRIL in humoral responses. We have been able to generate antibodies that detect APRIL protein in human tissues. The study of in situ APRIL expression showed that APRIL mainly regulates late stages of B-cell humoral responses. It also provided evidence that APRIL may modulate tumor development in patients, but only for specific B-cell malignancies. Here, we will review to what extent fine characterization of in situ expression adds valuable information on APRIL (patho) physiological functions.

Keywords
  • B-Cell Activating Factor/metabolism
  • B-Cell Activation Factor Receptor/metabolism
  • Cell Survival
  • Humans
  • Ligands
  • Lymphoma, B-Cell/*immunology/pathology
  • Models, Immunological
  • Plasma Cells/*metabolism
  • Tumor Necrosis Factor Ligand Superfamily Member 13/*immunology
Citation (ISO format)
BURJANADZE, Maka et al. In situ detection of APRIL-rich niches for plasma-cell survival and their contribution to B-cell lymphoma development. In: Histology and histopathology, 2009, vol. 24, n° 8, p. 1061–1066.
Identifiers
ISSN of the journal0213-3911
484views
0downloads

Technical informations

Creation04/23/2012 10:26:42 AM
First validation04/23/2012 10:26:42 AM
Update time03/14/2023 5:22:55 PM
Status update03/14/2023 5:22:55 PM
Last indexation01/15/2024 11:19:14 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack