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Title

Prevention, chemoradiation and surgery for anal cancer
Authors
Buchs, Nicolas
Allal, Abdelkarim Said
Morel, Philippe
Gervaz, Pascal
Published in Expert Review of Anticancer Therapy. 2009, vol. 9, no. 4, p. 483-489
Abstract Management of patients with squamous cell carcinoma of the anus (SCCA) has remained virtually unchanged since the 1980s. By contrast, the demographics of SCCA are evolving, with the emergence of a high-risk group of patients: HIV-positive male homosexuals are prone to develop anal intra-epithelial neoplasia and rapidly progress towards invasive SCCA. By many aspects, anal cancer is similar to uterine cervix cancer - a sexually transmitted disease driven by oncogenic human papillomavirus (HPV) infection. Thus, for many patients, SCCA results from the combination of two preventable diseases, HPV and HIV infection. This article reviews current evidence suggesting that a new, more preventive approach is needed in order to improve the clinical outcome of SCCA in HIV-positive patients.
Keywords Adolescent — Alphapapillomavirus/pathogenicity — *Anus Neoplasms/drug therapy/prevention & control/radiotherapy/surgery/virology — Carcinoma in Situ/surgery/virology — *Carcinoma, Squamous Cell/drug therapy/prevention & control/radiotherapy/surgery/virology — Combined Modality Therapy — Female — HIV Infections/complications — Homosexuality, Male — Humans — Male — Papillomavirus Infections/prevention & control — Papillomavirus Vaccines — Radiotherapy, Adjuvant/adverse effects — Salvage Therapy — Surgical Flaps — Surgical Wound Dehiscence/etiology/prevention & control — Vaccination
Identifiers
PMID: 19374601
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Structures
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group Chirurgie viscérale (104)
Citation
(ISO format) 		BUCHS, Nicolas et al. Prevention, chemoradiation and surgery for anal cancer. In: Expert Review of Anticancer Therapy, 2009, vol. 9, n° 4, p. 483-489. https://archive-ouverte.unige.ch/unige:19509

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Deposited on : 2012-04-23

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