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Scientific article
French

La viabilité des reins marginaux testée par perfusion de gadolinium sous IRM pendant leur réanimation

Contributors

Buchs, Jean-Bernard; Lazeyras, François; Buehler, Leo Hans; Vallée, Jean-Paul; Nastasi, A.; Ruttimann, R.; Morel, Philippe

Published in

Progrès en urologie, vol. 19, no. 5, p. 307-312

Publication date

2009

Abstract

INTRODUCTION: Marginal kidneys must be reanimated before their transplantation. Reanimation is conducted with hypothermic pulsatile perfusion. The tests used generally to demonstrate the viability is the vascular resistance which is not convenient for everybody. We have developed a magnetic resonance compatible perfusional technology allowing us to test the organs during the perfusion by Gd-perfusion MRI. METHODS AND RESULTS: We have used pigs' kidneys with no warm ischemic time to establish the basis in a normal kidney. After an eight-hour hypothermic pulsatile perfusion, kidneys are submitted to a Gd perfusion. First, we measure the anatomy of the vessels, then the distribution of Gd in the kidney. We obtain simultaneously a dynamic study of the organs where T0 represents the Gd bolus arrival in the cortex and TP the maximum saturation time of Gd. CONCLUSION: We have observed that a normal T0 is inferior to 30s and TP is inferior to one minute. We have compared these values with ATP resynthesis in these organs and found that they correlate. We hope for the future through that predictive use of Gd-MRI to avoid the clinical use of "too" marginal kidneys or the discard of good kidneys but not corresponding with the vascular resistance theory.

Keywords

  • Animals
  • *Contrast Media
  • Kidney/*radionuclide imaging
  • *Kidney Transplantation
  • *Magnetic Resonance Imaging
  • Meglumine/*diagnostic use
  • Organometallic Compounds/*diagnostic use
  • Swine
  • *Tissue Survival

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

BUCHS, Jean-Bernard et al. La viabilité des reins marginaux testée par perfusion de gadolinium sous IRM pendant leur réanimation. In: Progrès en urologie, 2009, vol. 19, n° 5, p. 307–312. doi: 10.1016/j.purol.2009.01.004

Identifiers

Journal ISSN

1166-7087
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Technical informations

Creation

23/04/2012 10:26:42

First validation

23/04/2012 10:26:42

Update

14/03/2023 17:22:54

Status update

14/03/2023 17:22:54

Last indexation

29/10/2024 19:23:18
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