Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome

Borel, Jean-Christian; Roux-Lombard, Pascale; Tamisier, Renaud; Arnaud, Claire; Monneret, Denis; Arnol, Nathalie; Baguet, Jean-Philippe; Levy, Patrick; Pepin, Jean-Louis

doi:10.1371/journal.pone.0006733

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Title		Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome
Authors		Borel, Jean-Christian Roux-Lombard, Pascale Tamisier, Renaud Arnaud, Claire Monneret, Denis Arnol, Nathalie Baguet, Jean-Philippe Levy, Patrick Pepin, Jean-Louis show all authors [1 - 9]
Published in		PloS one. 2009, vol. 4, no. 8, e6733
Abstract		BACKGROUND: Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown. QUESTION: To compare inflammatory status and endothelial function in OHS versus eucapnic obese patients. METHODOLOGY: 14 OHS and 39 eucapnic obese patients matched for BMI and age were compared. Diurnal blood gazes, overnight polysomnography and endothelial function, measured by reactive hyperemia peripheral arterial tonometry (RH-PAT), were assessed. Inflammatory (Leptin, RANTES, MCP-1, IL-6, IL-8, TNFalpha, Resistin) and anti-inflammatory (adiponectin, IL-1Ra) cytokines were measured by multiplex beads immunoassays. PRINCIPAL FINDINGS: OHS exhibited a higher PaCO(2), a lower forced vital capacity (FVC) and tended to have a lower PaO(2) than eucapnic obese patients. (HS)-CRP, RANTES levels and glycated haemoglobin (HbA1c) were significantly increased in OHS (respectively 11.1+/-10.9 vs. 5.7+/-5.5 mg x l(-1) for (HS)-CRP, 55.9+/-55.3 vs 23.3+/-15.8 ng/ml for RANTES and 7.3+/-4.3 vs 6.1+/-1.7 for HbA1c). Serum adiponectin was reduced in OHS (7606+/-2977 vs 13,660+/-7854 ng/ml). Endothelial function was significantly more impaired in OHS (RH-PAT index: 0.22+/-0.06 vs 0.51+/-0.11). CONCLUSIONS: Compared to eucapnic obesity, OHS is associated with a specific increase in the pro-atherosclerotic RANTES chemokine, a decrease in the anti-inflammatory adipokine adiponectin and impaired endothelial function. These three conditions are known to be strongly associated with an increased cardiovascular risk. TRIAL REGISTRATION: ClinicalTrials.gov NCT00603096.
Keywords		Aged — Body Mass Index — Case-Control Studies — Endothelium, Vascular/physiopathology — Female — Humans — Inflammation/physiopathology — Male — Middle Aged — Obesity Hypoventilation Syndrome/*physiopathology — Polysomnography
Identifiers		DOI: 10.1371/journal.pone.0006733 PMID: 19701463
Full text		Article - Free access Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2726948/pdf/pone.0006733.pdf
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Citation (ISO format)		BOREL, Jean-Christian et al. Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome. In: PloS one, 2009, vol. 4, n° 8, p. e6733. doi: 10.1371/journal.pone.0006733 https://archive-ouverte.unige.ch/unige:19503