From 15 days before to 60 days after metamorphosis, an immunologically specific tolerance to skin allografts between individuals of Xenopus can be induced by skin allografts. Genetic inheritance of histocompatibility antigens determines the degree of tolerance during metamorphosis: in individuals from the first generation, 25–50 % of the siblings were tolerant. In second generation individuals, the percentage of tolerance is 75–100 % when the parents show mutual tolerance to skin allografts at metamorphosis and only 25 % when the parents are mutually incompatible. In view of the characteristics of this tolerance it is suggested that it concerns mainly weak histocompatibility antigens and that it occurs preferentially at metamorphosis, as at this stage the animal becomes tolerant to many new self‐antigens.