Motor neuroscience and physics-based character animation (PBCA) approach human and humanoid control from different perspectives. The primary goal of PBCA is to control the movement of a ragdoll (humanoid or animal) applying forces and torques within a physical simulation. The primary goal of motor neuroscience is to understand the contribution of different parts of the nervous system to generate coordinated movements. We review the functional principles and the functional anatomy of human motor control and the main strategies used in PBCA. We then explore common research points by discussing the functional anatomy and ongoing debates in motor neuroscience from the perspective of PBCA. We also suggest there are several benefits to be found in studying sensorimotor integration and human-character coordination through closer collaboration between these two fields.