Scientific article
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English

The Cav3.3 calcium channel is the major sleep spindle pacemaker in thalamus

Publication date2011-08-16
First online date2011-08-01
Abstract

Low-threshold (T-type) Ca(2+) channels encoded by the Ca(V)3 genes endow neurons with oscillatory properties that underlie slow waves characteristic of the non-rapid eye movement (NREM) sleep EEG. Three Ca(V)3 channel subtypes are expressed in the thalamocortical (TC) system, but their respective roles for the sleep EEG are unclear. Ca(V)3.3 protein is expressed abundantly in the nucleus reticularis thalami (nRt), an essential oscillatory burst generator. We report the characterization of a transgenic Ca(V)3.3(-/-) mouse line and demonstrate that Ca(V)3.3 channels are indispensable for nRt function and for sleep spindles, a hallmark of natural sleep. The absence of Ca(V)3.3 channels prevented oscillatory bursting in the low-frequency (4-10 Hz) range in nRt cells but spared tonic discharge. In contrast, adjacent TC neurons expressing Ca(V)3.1 channels retained low-threshold bursts. Nevertheless, the generation of synchronized thalamic network oscillations underlying sleep-spindle waves was weakened markedly because of the reduced inhibition of TC neurons via nRt cells. T currents in Ca(V)3.3(-/-) mice were <30% compared with those in WT mice, and the remaining current, carried by Ca(V)3.2 channels, generated dendritic [Ca(2+)](i) signals insufficient to provoke oscillatory bursting that arises from interplay with Ca(2+)-dependent small conductance-type 2 K(+) channels. Finally, naturally sleeping Ca(V)3.3(-/-) mice showed a selective reduction in the power density of the σ frequency band (10-12 Hz) at transitions from NREM to REM sleep, with other EEG waves remaining unaltered. Together, these data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development.

Keywords
  • Animals
  • Brain Waves
  • Calcium Channels, T-Type / physiology
  • Calcium Signaling
  • Electroencephalography
  • Mice
  • Mice, Knockout
  • Neurons / physiology
  • Sleep / physiology
  • Sleep, REM
  • Thalamus / physiology
Affiliation entities Not a UNIGE publication
Citation (ISO format)
ASTORI, Simone et al. The Cav3.3 calcium channel is the major sleep spindle pacemaker in thalamus. In: Proceedings of the National Academy of Sciences of the United States of America, 2011, vol. 108, n° 33, p. 13823–13828. doi: 10.1073/pnas.1105115108
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Article (Published version)
accessLevelPublic
Identifiers
Additional URL for this publicationhttps://pnas.org/doi/full/10.1073/pnas.1105115108
Journal ISSN0027-8424
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