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Scientific article
English

Nuclear export of mRNA

Contributors

Zenklusen, D; Stutz, Françoise

Published in

FEBS letters, vol. 498, no. 2-3, p. 150-156

Publication date

2001

Abstract

Export of mRNA through nuclear pore complexes (NPC) is preceded by multiple and well coordinated processing steps, resulting in the formation of an export competent ribonucleoprotein complex (mRNP). Numerous factors involved in the translocation of the mRNP through the NPC and its release into the cytoplasm have been isolated mainly through genetic approaches in yeast, and putative functional homologues have been identified in metazoan systems. Understanding the mechanism of mRNA export relies, in part, on the functional characterization of these factors and the establishment of a complete network of molecular interactions. Here we summarize recent progress in the characterization of yeast and mammalian components implicated in the export of an mRNA from the nucleus to the cytoplasm.

Keywords

  • Active Transport, Cell Nucleus/physiology
  • Animals
  • Cell Nucleus/physiology
  • Heterogeneous-Nuclear Ribonucleoproteins
  • Humans
  • Models, Biological
  • Nuclear Pore/metabolism
  • Nuclear Proteins/metabolism
  • Nucleocytoplasmic Transport Proteins
  • Protein Binding
  • RNA, Messenger/metabolism
  • RNA-Binding Proteins/metabolism
  • Ribonucleoproteins/genetics/metabolism
  • Saccharomyces cerevisiae/genetics/metabolism
  • Saccharomyces cerevisiae Proteins

UNIGE affiliation entities

Citation (ISO format)

ZENKLUSEN, D, STUTZ, Françoise. Nuclear export of mRNA. In: FEBS letters, 2001, vol. 498, n° 2-3, p. 150–156. doi: 10.1016/s0014-5793(01)02482-6

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0014-5793
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Technical informations

Creation

13/04/2012 11:18:00

First validation

13/04/2012 11:18:00

Update

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