Scientific article
English

Pseudo-diffusion effects in lung MRI

Published inJournal of magnetic resonance, vol. 299, p. 1-11
Publication date2019-02
First online date2018-11-29
Abstract

Magnetic resonance imaging of lung tissue is strongly influenced by susceptibility effects between spin-bearing water molecules and air-filled alveoli. The measured lineshape, however, also depends on the interplay between susceptibility effects and blood-flow around alveoli that can be approximated as pseudo-diffusion. Both effects are quantitatively described by the Bloch-Torrey-equation, which was so far only solved for dephasing on the alveolar surface. In this work, we extend this model to the whole range of physiological relevant air volume fractions. The results agree very well with in vivo measurements in human lung tissue.

Keywords
  • Bloch-Torrey-equation
  • Lung MRI
  • Pseudo-diffusion effects
  • Susceptibility effects
Affiliation entities Not a UNIGE publication
Funding
  • Deutsche Forschungsgemeinschaft [DFG KU 3555/1-1]
Citation (ISO format)
ZIENER, C H et al. Pseudo-diffusion effects in lung MRI. In: Journal of magnetic resonance, 2019, vol. 299, p. 1–11. doi: 10.1016/j.jmr.2018.11.015
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1090-7807
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