Ubiquitin and assembly of export competent mRNP

Babour, Anna; Dargemont, Catherine; Stutz, Françoise

doi:10.1016/j.bbagrm.2011.12.006

Scientific article

English

Ubiquitin and assembly of export competent mRNP

Contributors

Babour, Anna; Dargemont, Catherine; Stutz, Françoise

Published in

Biochimica et biophysica acta, vol. 1819, no. 6, p. 521-530

Publication date

2012

Abstract

The production of mature and export competent mRNP (mRNA ribonucleoprotein) complexes depends on a series of highly coordinated processing reactions. RNA polymerase II (RNAPII) plays a central role in this process by mediating the sequential recruitment of mRNA maturation and export factors to transcribing genes, thereby establishing a strong functional link between transcription and export through nuclear pore complexes (NPC). Growing evidence indicates that post-translational modifications participate in the dynamic association of processing and export factors with mRNAs ensuring that the transitions and rearrangements undergone by the mRNP occur at the right time and place. This review mainly focuses on the role of ubiquitin conjugation in controlling mRNP assembly and quality control from transcription down to export through the NPC. It emphasizes the central role of ubiquitylation in organizing the chronology of events along this highly dynamic pathway. This article is part of a Special Issue entitled: Nuclear Transport and RNA Processing.

UNIGE affiliation entities

Faculté des sciences / Section de biologie / Département de biologie cellulaire

Citation (ISO format)

BABOUR, Anna, DARGEMONT, Catherine, STUTZ, Françoise. Ubiquitin and assembly of export competent mRNP. In: Biochimica et biophysica acta, 2012, vol. 1819, n° 6, p. 521–530. doi: 10.1016/j.bbagrm.2011.12.006

Article (Published version)

Identifiers

PID : unige:19418
DOI : 10.1016/j.bbagrm.2011.12.006
PMID : 22240387

Journal ISSN

0006-3002

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13/04/2012 09:11:00

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14/03/2023 17:22:26

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Ubiquitin and assembly of export competent mRNP

Contributors

Published in

Publication date

Abstract

UNIGE affiliation entities

Citation (ISO format)

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Creation

First validation

Update

Status update

Last indexation