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Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones

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Published in Organic Letters. 2012, vol. 14, no. 7, p. 1842-1845
Abstract Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.
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MUELLER, Daniel, ALEXAKIS, Alexandre. Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones. In: Organic Letters, 2012, vol. 14, n° 7, p. 1842-1845. https://archive-ouverte.unige.ch/unige:19416

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Deposited on : 2012-04-17

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