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Scientific article
English

Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones

Published inOrganic letters, vol. 14, no. 7, p. 1842-1845
Publication date2012
Abstract

Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.

Citation (ISO format)
MUELLER, Daniel, ALEXAKIS, Alexandre. Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones. In: Organic letters, 2012, vol. 14, n° 7, p. 1842–1845. doi: 10.1021/ol3004436
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ISSN of the journal1523-7052
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Creation04/10/2012 2:02:00 PM
First validation04/10/2012 2:02:00 PM
Update time03/14/2023 5:22:25 PM
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