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Titles listCopper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones
Titles listCopper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones
Scientific Article
unige:19416 
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Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones |
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| Authors | ||
| Published in | Organic Letters. 2012, vol. 14, no. 7, p. 1842-1845 | |
| Abstract | Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity. | |
| Identifiers | DOI: 10.1021/ol3004436 | |
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| Citation (ISO format) | MUELLER, Daniel, ALEXAKIS, Alexandre. Copper-Catalyzed Asymmetric 1,4-Addition of Alkenyl Alanes to N-Substituted-2-3-dehydro-4-piperidones. In: Organic Letters, 2012, vol. 14, n° 7, p. 1842-1845. doi: 10.1021/ol3004436 https://archive-ouverte.unige.ch/unige:19416 |
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