Scientific article
Case report
OA Policy
English

Regressive Neuroblastoma : Widely Accepted, Underreported Histology

Published inClinical case reports, vol. 14, e72640
Publication date2026-05
First online date2026-04-29
Abstract

Neuroblastoma accounts for approximately 8% of all pediatric cancers and up to 15% of pediatric cancer-related deaths in malignant cases; neuroblastoma is the most common malignancy in infancy. Notably, up to 50% of tumors may undergo spontaneous regression without treatment. However, detailed histological descriptions of regressed neuroblastoma remain limited in the literature. We report the histological features of a particularly illustrative case, characterized by edema, mild collagen deposition, evidence of prior hemorrhage, and calcifications. Cellularity was minimal, consisting of rare, scattered mature-appearing ganglion cells, without neuropil or neuroblastic clusters. Accurate recognition of these morphological features in surgical specimens is essential for optimal treatment planning.

Keywords
  • Differentiation
  • Fibrosis
  • Maturation
  • Mature ganglion cells
  • Regressed neuroblastoma
  • Spontaneous regression
Citation (ISO format)
MEMBREZ, Tom et al. Regressive Neuroblastoma : Widely Accepted, Underreported Histology. In: Clinical case reports, 2026, vol. 14, p. e72640. doi: 10.1002/ccr3.72640
Main files (1)
Article (Published version)
Identifiers
Journal ISSN2050-0904
4views
44downloads

Technical informations

Creation22/05/2026 14:55:23
First validation15/06/2026 14:50:12
Update15/06/2026 14:50:12
Status update15/06/2026 14:50:12
Last indexation15/06/2026 14:50:13
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack