Since the nineties, we note a diversification of recreational drugs and an increase in intoxications requiring medical care. From cannabis to cocaine through the New Psychoactive Substances, the aim of this article is to focus on Gamma-hydroxybutyrate (GHB), lysergic diethylamid acid (LSD) and 3,4-methylenedioxymethamphetamin (MDMA), three substances that we are confronted with in our emergency rooms and review the effective care to provide in case of intoxication.