Scientific article
English

Comprehensive geriatric assessment and comorbidities predict survival in geriatric oncology

Published inActa clinica belgica, vol. 71, no. 4, p. 206-213
Publication date2016-08
First online date2016-05-12
Abstract

Objectives: The comprehensive geriatric assessment (CGA) can detect geriatric problems and potentially improve survival, physical, and cognitive state of patients, as well as increase an older person's chances of staying at home longer. In older people, the number and severity of comorbidity increase with age and are an important determinant of survival. The aim of the study was to assess to which extent CGA and comorbidities could be seen as determinants of survival.

Materials and methods: This study analyzed data from two hospitals that included geriatric assessments of patients aged 70 years and more with cancer linked to mortality. Logistic regression was used to model survival predictors.

Results: Two hundred and five various cancer patients (47% females) with a median age of 79 were included. They presented with a lot of undiagnosed geriatric problems. Screening scales (G8, SEGA), cognitive, and psychological disorders, and low albumin levels appeared to be independent survival factors. A frailty profile classification was associated with higher mortality. The average comorbidity was graded 2 according to the Charlson scale. By the geriatric cumulative illness rating scale (CIRS-G), the arithmetic average number of affected organ systems was 5 (range 0-10) in all patients. Cardiovascular disorders were the most common comorbidity. Renal insufficiency and anaemia were negatively associated with survival.

Conclusion: Old cancer patients present a lot of comorbidities and newly diagnosed geriatric problems. Several tools provide determinants of survival in old cancer patients. Prospective trials evaluating the utility of a CGA to guide interventions to improve quality of cancer care in older adults are justified.

Keywords
  • Cancer
  • Comorbidity
  • Elderly
  • Geriatric assessment
  • Survival
  • Aged
  • Aged, 80 and over
  • Female
  • Geriatric Assessment
  • Humans
  • Logistic Models
  • Male
  • Neoplasms / diagnosis
  • Neoplasms / epidemiology
  • Neoplasms / mortality
  • Risk Factors
Affiliation entities Not a UNIGE publication
Citation (ISO format)
DENEWET, Nathalie et al. Comprehensive geriatric assessment and comorbidities predict survival in geriatric oncology. In: Acta clinica belgica, 2016, vol. 71, n° 4, p. 206–213. doi: 10.1080/17843286.2016.1153816
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN1784-3286
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