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PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation
|Published in||Transplant International. 2008, vol. 21, no. 11, p. 1015-1028|
|Abstract||Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins.|
|Keywords||Animals — Antibodies, Monoclonal/pharmacology — Antigen-Presenting Cells/*immunology — Antigens, CD/immunology/*physiology — Antigens, CD274 — Antigens, CD80/immunology — Apoptosis Regulatory Proteins/*physiology — B7 Antigens — Graft Rejection/immunology — Humans — Intercellular Signaling Peptides and Proteins/physiology — Mice — Programmed Cell Death 1 Ligand 2 Protein — Programmed Cell Death 1 Receptor — Receptors, Immunologic/immunology — Receptors, Tumor Necrosis Factor, Member 14/immunology — Signal Transduction/immunology — T-Lymphocytes, Regulatory/drug effects/immunology — Transplantation Immunology/*immunology|
|Research group||Cultures cellulaires et transplantations (519)|
|DEL RIO, Maria-Luisa et al. PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. In: Transplant International, 2008, vol. 21, n° 11, p. 1015-1028. doi: 10.1111/j.1432-2277.2008.00726.x https://archive-ouverte.unige.ch/unige:19224|