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PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation

del Rio, Maria-Luisa
Gibbons, Carrie
Tian, Jiong
Rodriguez-Barbosa, Jose-Ignacio
Published in Transplant international. 2008, vol. 21, no. 11, p. 1015-1028
Abstract Transplantation of cells, tissues and vascularized solid organs is a successful therapeutic intervention for many end-stage chronic diseases. The combination of co-stimulatory blockade with the delivery of negative signals to T cells through co-inhibitory receptors would provide a robust approach to modulating T-cell receptor signaling and improving alloantigen-specific control of transplant rejection. This approach based on fundamental knowledge of APC/T-cell interactions may complement conventional therapies in the near future to reinforce long-term allograft survival, and permit minimal immunosuppression. The focus of this review was primarily on two major co-inhibitory signaling pathways, namely PD-1/PD-L1/PD-L2 and BTLA/CD160/HVEM/LIGHT that have been thoroughly characterized in murine models of transplantation using genetically modified mice, specific monoclonal antibodies and fusion proteins.
Keywords AnimalsAntibodies, Monoclonal/pharmacologyAntigen-Presenting Cells/*immunologyAntigens, CD/immunology/*physiologyAntigens, CD274Antigens, CD80/immunologyApoptosis Regulatory Proteins/*physiologyB7 AntigensGraft Rejection/immunologyHumansIntercellular Signaling Peptides and Proteins/physiologyMiceProgrammed Cell Death 1 Ligand 2 ProteinProgrammed Cell Death 1 ReceptorReceptors, Immunologic/immunologyReceptors, Tumor Necrosis Factor, Member 14/immunologySignal Transduction/immunologyT-Lymphocytes, Regulatory/drug effects/immunologyTransplantation Immunology/*immunology
PMID: 18662368
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Research group Cultures cellulaires et transplantations (519)
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DEL RIO, Maria-Luisa et al. PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation. In: Transplant international, 2008, vol. 21, n° 11, p. 1015-1028. doi: 10.1111/j.1432-2277.2008.00726.x https://archive-ouverte.unige.ch/unige:19224

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Deposited on : 2012-03-27

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