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Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism

Donze, Jacques
Le Gal, Gregoire
Fine, Michael J.
Roy, Pierre-Marie
Sanchez, Olivier
Verschuren, Franck
Meyer, Guy
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Published in Thrombosis and haemostasis. 2008, vol. 100, no. 5, p. 943-948
Abstract Practice guidelines recommend outpatient care for selected patients with non-massive pulmonary embolism (PE), but fail to specify how these low-risk patients should be identified. Using data from U.S. patients, we previously derived the Pulmonary Embolism Severity Index (PESI), a prediction rule that risk stratifies patients with PE. We sought to validate the PESI in a European patient cohort. We prospectively validated the PESI in patients with PE diagnosed at six emergency departments in three European countries. We used baseline data for the rule's 11 prognostic variables to stratify patients into five risk classes (I-V) of increasing probability of mortality. The outcome was overall mortality at 90 days after presentation. To assess the accuracy of the PESI to predict mortality, we estimated the sensitivity, specificity, and predictive values for low- (risk classes I/II) versus higher-risk patients (risk classes III-V), and the discriminatory power using the area under the receiver operating characteristic (ROC) curve. Among 357 patients with PE, overall mortality was 5.9%, ranging from 0% in class I to 17.9% in class V. The 186 (52%) low-risk patients had an overall mortality of 1.1% (95% confidence interval [CI]: 0.1-3.8%) compared to 11.1% (95% CI: 6.8-16.8%) in the 171 (48%) higher-risk patients. The PESI had a high sensitivity (91%, 95% CI: 71-97%) and a negative predictive value (99%, 95% CI: 96-100%) for predicting mortality. The area under the ROC curve was 0.78 (95% CI: 0.70-0.86). The PESI reliably identifies patients with PE who are at low risk of death and who are potential candidates for outpatient care. The PESI may help physicians make more rational decisions about hospitalization for patients with PE.
Keywords AgedAged, 80 and overAmbulatory CareEurope/epidemiologyFemaleHospitalizationHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesPulmonary Embolism/*diagnosis/etiology/mortality/therapyROC CurveReproducibility of ResultsRisk AssessmentRisk FactorsSensitivity and Specificity*Severity of Illness IndexTime Factors
PMID: 18989542
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Research groups Groupe Perrier Arnaud (Médecine interne générale, de réhabilitation et de gériatrie) (585)
La maladie thromboembolique veineuse (808)
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DONZE, Jacques et al. Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism. In: Thrombosis and haemostasis, 2008, vol. 100, n° 5, p. 943-948. https://archive-ouverte.unige.ch/unige:19221

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Deposited on : 2012-03-27

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