Large magnitude snow avalanches (destructive size ≥ D3) impact settlements, transportation corridors, and public safety worldwide. In Colorado, United States, avalanches have killed more people than any other natural hazard since 1950. In March 2019, a large magnitude avalanche cycle occurred throughout the entire mountainous portion of Colorado resulting in more than 1000 reported avalanches during a two-week period. Nearly 200 of these avalanches were size D4 or larger with at least three D5 avalanches. However, placing this 2019 large magnitude avalanche cycle in historic context requires data prior to the instrumental record. Here, we paired tree disturbance data from dendrochronology (1698 to 2020) with meteorological data from the modeled and instrumental record (1901 to 2020) to understand the frequency and climate drivers of large magnitude snow avalanche cycles. The extensive number of downed trees from the 2019 avalanche cycle allowed us to collect 1,188 cross-sections and cores from 1023 individual trees within 24 avalanche paths across the state. From these samples we identified 4135 avalanche-related growth disturbances. We employed a strategic nested sampling design to spatially aggregate avalanche frequency from individual avalanche paths, to counties, to three major sub-regions (i.e., north, central, and south), and across the entire region (i.e., state of Colorado). Over a period spanning more than three centuries (1698 to 2020), we identified 76 avalanche years within 24 individual avalanche paths. Large magnitude avalanche event frequency varied across paths and sub-regions with several notable region-wide avalanche cycles. Both tree-ring and historical written records highlighted 1899 as a year with widespread and large magnitude avalanche activity similar to the March 2019 avalanche cycle. Since the early-20th century (1900 to 2020) regional avalanche probability declined significantly in parallel with decreasing snowpack throughout Colorado. Similarly, dominant avalanche regimes shifted from large magnitude regional cycles driven by above average snowfall years over most of the record, to regional avalanche cycles occurring more commonly in average to low snow years since 1988. In recent decades, a lack of December precipitation and above average March precipitation characterized years with regional large magnitude avalanche activity. Even with declining snow water equivalent, truly extreme regional large magnitude avalanche cycles remain possible – as demonstrated by the 2019 cycle. This underscores that rare but high-impact events are not eliminated by long-term trends. Understanding the changing snow and weather drivers and subsequent behavior of large magnitude avalanche cycles across multiple spatial scales may improve avalanche forecasting and the products and mitigations strategies developed by structural engineers to mitigate avalanche danger. This can decrease the avalanche risk to the public and improve infrastructure design in avalanche terrain.