This work explores the generation of James Webb Space Telescope (JWSP) imagery via image-to-image translation from the available Hubble Space Telescope (HST) data. Comparative analysis encompasses the Pix2Pix, CycleGAN, TURBO, and DDPM-based Palette methodologies, assessing the criticality of image registration in astronomy. While the focus of this study is not on the scientific evaluation of model fairness, we note that the techniques employed may bear some limitations and the translated images could include elements that are not present in actual astronomical phenomena. To mitigate this, uncertainty estimation is integrated into our methodology, enhancing the translation's integrity and assisting astronomers in distinguishing between reliable predictions and those of questionable certainty. The evaluation was performed using metrics including MSE, SSIM, PSNR, LPIPS, and FID. The paper introduces a novel approach to quantifying uncertainty within image translation, leveraging the stochastic nature of DDPMs. This innovation not only bolsters our confidence in the translated images but also provides a valuable tool for future astronomical experiment planning. By offering predictive insights when JWST data are unavailable, our approach allows for informed preparatory strategies for making observations with the upcoming JWST, potentially optimizing its precious observational resources. To the best of our knowledge, this work is the first attempt to apply image-to-image translation for astronomical sensor-to-sensor translation.