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Paraoxonase 1: genetics and activities during aging

Marchegiani, Francesca
Marra, Maurizio
Olivieri, Fabiola
Cardelli, Maurizio
Boemi, Massimo
Franceschi, Claudio
Published in Rejuvenation Research. 2008, vol. 11, no. 1, p. 113-127
Abstract The increasing longevity of the population, one of the most important issues throughout the planet, is a very complex phenomenon (trait), likely resulting from a variety of environmental determinants interacting with and modulated by genetic mechanisms, mostly devoted to maintenance and repair. In fact, the genes involved in longevity impact upon basic processes such as inflammation, glucose and energy utilization, and oxidative stress. Based on the free radical theory of aging, in the past few years we have focused our attention on an enzyme that protects lipids from peroxidative damage-paraoxonase 1 (PON1). PON1 has been widely investigated, especially for its involvement in atherosclerosis and age-related diseases. In this review, we summarize data on the role played by PON1 on aging and its possible involvement in human longevity, focusing on the relationship between genetic polymorphisms and enzyme activity and its capability to counteract oxidative stress.
Keywords Aging/*genetics/physiologyAnimalsAryldialkylphosphatase/*genetics/metabolism/*physiologyAtherosclerosis/geneticsGenetic Variation/physiologyHumans
PMID: 18279029
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Research group Lipoprotéines sériques (598)
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MARCHEGIANI, Francesca et al. Paraoxonase 1: genetics and activities during aging. In: Rejuvenation Research, 2008, vol. 11, n° 1, p. 113-127. doi: 10.1089/rej.2007.0582 https://archive-ouverte.unige.ch/unige:19208

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Deposited on : 2012-03-27

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