This paper presents a comprehensive review of both the theory and experimental successes of Quantum Chromodynamics, starting with its emergence as a well defined theory in 1972-73 and following developments and results up to the present day. Topics include a review of the earliest theoretical and experimental foundations; the fundamental constants of QCD; an introductory discussion of lattice QCD, the only known method for obtaining exact predictions from QCD; methods for approximating QCD, with special focus on effective field theories; QCD under extreme conditions; measurements and predictions of meson and baryon states; a special discussion of the structure of the nucleon; techniques for study of QCD at high energy, including treatment of jets and showers; measurements at colliders; weak decays and quark mixing; and a section on the future, which discusses new experimental facilities or upgrades currently funded. The paper is intended to provide a broad background for Ph.D. students and postdocs starting their career. Some contributions include personal accounts of how the ideas or experiments were developed.