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Title

Proteomic analysis of a podocyte vesicle-enriched fraction from human normal and pathological urine samples
Authors
Lescuyer, Pierre
Pernin, Agnes
Hainard, Alexandre
Bigeire, Caty
Burgess, Jennifer
Zimmermann, Catherine
Sanchez, Jean-Charles
Schifferli, Jurg
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Published in Proteomics - Clinical Applications. 2008, vol. 2, no. 7-8, p. 1008-1018
Abstract Podocytes (glomerular visceral epithelial cells) release vesicles into urine. Podocyte vesicle-enriched fractions from normal and pathological human urine samples were prepared for proteomic analysis. An immunoadsorption method was applied and enrichment of podocyte vesicles was assessed. We identified 76 unique proteins. One protein, serum paraoxonase/arylesterase 1 (PON-1), was newly identified in normal human urine sample. We confirmed this result and showed PON-1 expression in normal human kidney. These results demonstrated the potential for using the urine samples enriched in podocyte vesicles as a starting material in studies aimed at discovery of biomarkers for diseases.
Identifiers
PMID: 21136901
Full text
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Other version: http://onlinelibrary.wiley.com/store/10.1002/prca.200800033/asset/1008_ftp.pdf?v=1&t=gyd1eqlu&s=11f5f759be4d2d5a21aa4...
Structures
Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique
Research groups La protéomique au service de la clinique (270)
Groupe de Protéomique biomédicale (635)
Analyse protéomique et Analyse génomique des maladies rénales (659)
Citation
(ISO format) 		LESCUYER, Pierre et al. Proteomic analysis of a podocyte vesicle-enriched fraction from human normal and pathological urine samples. In: Proteomics - Clinical Applications, 2008, vol. 2, n° 7-8, p. 1008-1018. doi: 10.1002/prca.200800033 https://archive-ouverte.unige.ch/unige:19207

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Deposited on : 2012-03-27

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