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Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity

Dalal, Sarang S.
Edwards, Erik
Sekihara, Kensuke
Findlay, Anne M.
Canolty, Ryan T.
Berger, Mitchel S.
Knight, Robert T.
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Published in Neuroimage. 2008, vol. 40, no. 4, p. 1686-1700
Abstract The spatiotemporal dynamics of cortical oscillations across human brain regions remain poorly understood because of a lack of adequately validated methods for reconstructing such activity from noninvasive electrophysiological data. In this paper, we present a novel adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction from magnetoencephalography (MEG) and electroencephalography (EEG) data. The efficacy of the method is demonstrated with simulated sources and is also applied to real MEG data from a self-paced finger movement task. The algorithm reliably reveals modulations both in the beta band (12-30 Hz) and high gamma band (65-90 Hz) in sensorimotor cortex. The performance is validated by both across-subjects statistical comparisons and by intracranial electrocorticography (ECoG) data from two epilepsy patients. Interestingly, we also reliably observed high frequency activity (30-300 Hz) in the cerebellum, although with variable locations and frequencies across subjects. The proposed algorithm is highly parallelizable and runs efficiently on modern high-performance computing clusters. This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition.
Keywords AdultAlgorithmsBeta RhythmCerebellum/anatomy & histology/physiologyCerebral Cortex/anatomy & histology/*physiologyData Interpretation, StatisticalElectroencephalographyElectrophysiologyFemaleFingers/innervation/physiologyHumansImage Processing, Computer-Assisted/*methodsMagnetoencephalographyMaleMotor Cortex/anatomy & histology/physiologyPsychomotor Performance/physiologySomatosensory Cortex/anatomy & histology/physiology
PMID: 18356081
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Research group Neuroréhabilitation assistée par imagerie (910)
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DALAL, Sarang S. et al. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. In: Neuroimage, 2008, vol. 40, n° 4, p. 1686-1700. https://archive-ouverte.unige.ch/unige:19186

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Deposited on : 2012-03-27

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