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Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity
|Published in||Neuroimage. 2008, vol. 40, no. 4, p. 1686-1700|
|Abstract||The spatiotemporal dynamics of cortical oscillations across human brain regions remain poorly understood because of a lack of adequately validated methods for reconstructing such activity from noninvasive electrophysiological data. In this paper, we present a novel adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction from magnetoencephalography (MEG) and electroencephalography (EEG) data. The efficacy of the method is demonstrated with simulated sources and is also applied to real MEG data from a self-paced finger movement task. The algorithm reliably reveals modulations both in the beta band (12-30 Hz) and high gamma band (65-90 Hz) in sensorimotor cortex. The performance is validated by both across-subjects statistical comparisons and by intracranial electrocorticography (ECoG) data from two epilepsy patients. Interestingly, we also reliably observed high frequency activity (30-300 Hz) in the cerebellum, although with variable locations and frequencies across subjects. The proposed algorithm is highly parallelizable and runs efficiently on modern high-performance computing clusters. This method enables the ultimate promise of MEG and EEG for five-dimensional imaging of space, time, and frequency activity in the brain and renders it applicable for widespread studies of human cortical dynamics during cognition.|
|Keywords||Adult — Algorithms — Beta Rhythm — Cerebellum/anatomy & histology/physiology — Cerebral Cortex/anatomy & histology/*physiology — Data Interpretation, Statistical — Electroencephalography — Electrophysiology — Female — Fingers/innervation/physiology — Humans — Image Processing, Computer-Assisted/*methods — Magnetoencephalography — Male — Motor Cortex/anatomy & histology/physiology — Psychomotor Performance/physiology — Somatosensory Cortex/anatomy & histology/physiology|
|Research group||Neuroréhabilitation assistée par imagerie (910)|
|DALAL, Sarang S. et al. Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. In: Neuroimage, 2008, vol. 40, n° 4, p. 1686-1700. https://archive-ouverte.unige.ch/unige:19186|