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Are parkin patients particularly suited for deep-brain stimulation?

Lohmann, Ebba
Welter, Marie-Laure
Fraix, Valerie
Lesage, Suzanne
Laine, Sophie
Tanguy, Marie-Laure
Houeto, Jean-Luc
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Published in Movement disorders. 2008, vol. 23, no. 5, p. 740-743
Abstract Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.
Keywords AdultAgedAntiparkinson Agents/adverse effects/therapeutic useDNA Mutational Analysis*Deep Brain StimulationDyskinesia, Drug-InducedFemaleFollow-Up StudiesGenetic TestingHeterozygoteHomozygoteHumansLevodopa/adverse effects/therapeutic useMaleMiddle AgedMutationParkinsonian Disorders/*genetics/*therapyTreatment OutcomeUbiquitin-Protein Ligases/*genetics
PMID: 18228569
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Research group Maladie de Parkinson (911)
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LOHMANN, Ebba et al. Are parkin patients particularly suited for deep-brain stimulation?. In: Movement disorders, 2008, vol. 23, n° 5, p. 740-743. doi: 10.1002/mds.21903 https://archive-ouverte.unige.ch/unige:19175

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Deposited on : 2012-03-27

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