Scientific article

Are parkin patients particularly suited for deep-brain stimulation?

Published inMovement disorders, vol. 23, no. 5, p. 740-743
Publication date2008

Patients with parkin mutations are known to have slower PD progression and a better response to levodopa at lower doses than patients with idiopathic Parkinson's disease. To determine the effects of deep brain stimulation (DBS) on such patients, we have compared the follow-up after surgery of 7 patients with one parkin mutation, 7 patients with two parkin mutations, and 39 patients without parkin mutations. Twelve to 24 months after neurosurgery, the daily doses of levodopa equivalent were significantly lower in patients with two parkin mutations, indicating that these patients benefit from DBS, and they might have more durable results.

  • Adult
  • Aged
  • Antiparkinson Agents/adverse effects/therapeutic use
  • DNA Mutational Analysis
  • *Deep Brain Stimulation
  • Dyskinesia, Drug-Induced
  • Female
  • Follow-Up Studies
  • Genetic Testing
  • Heterozygote
  • Homozygote
  • Humans
  • Levodopa/adverse effects/therapeutic use
  • Male
  • Middle Aged
  • Mutation
  • Parkinsonian Disorders/*genetics/*therapy
  • Treatment Outcome
  • Ubiquitin-Protein Ligases/*genetics
Citation (ISO format)
LOHMANN, Ebba et al. Are parkin patients particularly suited for deep-brain stimulation? In: Movement disorders, 2008, vol. 23, n° 5, p. 740–743. doi: 10.1002/mds.21903
Updates (1)
ISSN of the journal0885-3185

Technical informations

Creation03/27/2012 9:23:50 AM
First validation03/27/2012 9:23:50 AM
Update time03/14/2023 5:21:06 PM
Status update03/14/2023 5:21:05 PM
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