We employ the Fuzzy Sphere regulator to study the 3D Lee-Yang CFT. The model is defined by deforming the Ising model on the Fuzzy Sphere via a purely imaginary longitudinal magnetic field. This model undergoes a quantum phase transition, whose critical point we determine and identify with the 3D Lee-Yang CFT. We show how to tune the model and find that the lowest-lying states of the Hamiltonian align well with the expected CFT spectrum. We discuss the Fuzzy Sphere estimates for the scaling dimension ∆$_{ϕ}$ of the lowest primary operator. Finally, we interpret small deviations from the CFT expectations in terms of the leading irrelevant operators of the Lee-Yang CFT. We show that the Fuzzy Sphere calculations are compatible with the best five-loop ϵ-expansion estimates.