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Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo

Klopfleisch, Steve
Schmitz, Matthias
Kloppner, Sabine
Schedensack, Mariann
Jeserich, Gunnar
Althaus, Hans H.
Bruck, Wolfgang
Published in The journal of neuroscience. 2008, vol. 28, no. 50, p. 13609-13614
Abstract Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small GTPases. Statins are thus considered as potential therapeutic drug for the inflammatory demyelinating disease multiple sclerosis (MS). However, little is known about the effects of statins on myelin-forming oligodendrocytes. Here, we show that statins hamper process and myelin formation in vitro by interfering with Ras and Rho signaling in mature oligodendrocytes and provide evidence that statins impair ongoing remyelination in vivo. Our findings may have significant implications for the application of statins in MS patients and in other demyelinating diseases of the CNS.
Keywords AnimalsCells, CulturedFemaleHydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacologyImmunoblottingMiceMice, Inbred C57BLMyelin Sheath/*drug effectsOligodendroglia/*drug effectsSignal Transduction/*drug effectsSwineRas Proteins/drug effectsRho GTP-Binding Proteins/drug effects
PMID: 19074034
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Other version: http://www.jneurosci.org/content/28/50/13609.full.pdf
Research group La Sclérose en plaques (908)
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KLOPFLEISCH, Steve et al. Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo. In: Journal of Neuroscience, 2008, vol. 28, n° 50, p. 13609-13614. doi: 10.1523/JNEUROSCI.2765-08.2008 https://archive-ouverte.unige.ch/unige:19150

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Deposited on : 2012-03-27

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