Scientific article

Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo

Published inThe Journal of neuroscience, vol. 28, no. 50, p. 13609-13614
Publication date2008

Statins are widely prescribed drugs in cardiovascular diseases. Recent studies also demonstrated anti-inflammatory and immunomodulatory properties of statins by modulating the activity of small GTPases. Statins are thus considered as potential therapeutic drug for the inflammatory demyelinating disease multiple sclerosis (MS). However, little is known about the effects of statins on myelin-forming oligodendrocytes. Here, we show that statins hamper process and myelin formation in vitro by interfering with Ras and Rho signaling in mature oligodendrocytes and provide evidence that statins impair ongoing remyelination in vivo. Our findings may have significant implications for the application of statins in MS patients and in other demyelinating diseases of the CNS.

  • Animals
  • Cells, Cultured
  • Female
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
  • Immunoblotting
  • Mice
  • Mice, Inbred C57BL
  • Myelin Sheath/*drug effects
  • Oligodendroglia/*drug effects
  • Signal Transduction/*drug effects
  • Swine
  • Ras Proteins/drug effects
  • Rho GTP-Binding Proteins/drug effects
Citation (ISO format)
KLOPFLEISCH, Steve et al. Negative impact of statins on oligodendrocytes and myelin formation in vitro and in vivo. In: The Journal of neuroscience, 2008, vol. 28, n° 50, p. 13609–13614. doi: 10.1523/JNEUROSCI.2765-08.2008
Updates (1)
ISSN of the journal0270-6474

Technical informations

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