Scientific article

Preserved decision making ability in early multiple sclerosis

Published inJournal of neurology, vol. 255, no. 11, p. 1762-1769
Publication date2008

BACKGROUND: The purpose of this study was to assess decision making in patients with multiple sclerosis (MS) at the earliest clinically detectable time point of the disease. METHODS: Patients with definite MS (n = 109) or with clinically isolated syndrome (CIS, n = 56), a disease duration of 3 months to 5 years, and no or only minor neurological impairment (Expanded Disability Status Scale [EDSS] score 0-2.5) were compared to 50 healthy controls using the Iowa Gambling Task (IGT). RESULTS: The performance of definite MS, CIS patients, and controls was comparable for the two main outcomes of the IGT (learning index: p = 0.7; total score: p = 0.6). The IGT learning index was influenced by the educational level and the co-occurrence of minor depression. CIS and MS patients developing a relapse during an observation period of 15 months dated from IGT testing demonstrated a lower learning index in the IGT than patients who had no exacerbation (p = 0.02). When controlling for age, gender and education, the difference between relapsing and non-relapsing patients was at the limit of significance (p = 0.06). CONCLUSION: Decision making in a task mimicking real life decisions is generally preserved in early MS patients as compared to controls. A possible consequence of MS relapsing activity in the impairment of decision making ability is also suspected in the early phase of MS.

  • Adolescent
  • Adult
  • Aged
  • Data Interpretation, Statistical
  • *Decision Making
  • Demyelinating Diseases/*psychology
  • Depression/psychology
  • Educational Status
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis/*psychology
  • Neuropsychological Tests
  • Recurrence
  • Young Adult
Citation (ISO format)
SIMIONI, Samanta et al. Preserved decision making ability in early multiple sclerosis. In: Journal of neurology, 2008, vol. 255, n° 11, p. 1762–1769. doi: 10.1007/s00415-008-0025-5
Main files (1)
ISSN of the journal0340-5354

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