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Title

The dynamic interplay between a cell fate determinant and a lysozyme homolog drives the asymmetric division cycle of Caulobacter crescentus

Authors
Thanbichler, Martin
Published in Genes and Development. 2008, vol. 22, no. 2, p. 212-225
Abstract Caulobacter crescentus divides asymmetrically into a swarmer cell and a stalked cell, a process that is governed by the imbalance in phosphorylated levels of the DivK cell fate determinant in the two cellular compartments. The asymmetric polar localization of the DivJ kinase results in its specific inheritance in the stalked daughter cell where it phosphorylates DivK. The mechanism for the polar positioning of DivJ is poorly understood. SpmX, an uncharacterized lysozyme homolog, is shown here to control DivJ localization and activation. In the absence of SpmX, DivJ is delocalized and dysfunctional, resulting in developmental defects caused by an insufficiency in phospho-DivK. While SpmX stimulates DivK phosphorylation in the stalked cell, unphosphorylated DivK in the swarmer cell activates an intricate transcriptional cascade that leads to the production of the spmX message. This event primes the swarmer cell for the impending transition into a stalked cell, a transition that is sparked by the abrupt accumulation and localization of SpmX to the future stalked cell pole. Localized SpmX then recruits and stimulates DivJ, and the resulting phospho-DivK implements the stalked cell fate. The dynamic interplay between SpmX and DivK is at the heart of the molecular circuitry that sustains the Caulobacter developmental cycle.
Keywords Bacterial Proteins/physiologyCaulobacter crescentus/*physiologyCell Cycle*Cell DivisionCell PolarityGene Expression Regulation, BacterialMuramidase/chemistryPhosphorylation
Identifiers
PMID: 18198338
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Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://genesdev.cshlp.org/content/22/2/212.full.pdf
Structures
Research group Régulation du cycle cellulaire dans C.crescentus, une bactérie asymétrique (895)
Citation
(ISO format)
RADHAKRISHNAN, Sunish Kumar, THANBICHLER, Martin, VIOLLIER, Patrick. The dynamic interplay between a cell fate determinant and a lysozyme homolog drives the asymmetric division cycle of Caulobacter crescentus. In: Genes and Development, 2008, vol. 22, n° 2, p. 212-225. https://archive-ouverte.unige.ch/unige:19104

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Deposited on : 2012-03-27

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