Scientific article

Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program

Published inEuropean journal of human genetics, vol. 16, no. 12, p. 1507-1511
Publication date2008

Essential hypertension is a principal cardiovascular risk factor whose origin remains unknown. Classical genetic studies have shown that blood pressure is at least partially heritable, opening a window to understanding the pathophysiology of essential hypertension in the human using modern genetic tools. The Wellcome Trust Case Control Consortium has recently published the results of screening the genomes of 2000 essential hypertension cases and 3000 controls using 500 000 genome-wide single nucleotide polymorphisms (SNPs). None of the variants proved to be genome-wide significant after correction for multiple tests but the most significantly associated SNPs (P<10(-5)) constitute a priority list that warrant follow-up in other studies. We describe here replication studies of the top six SNPs in subjects from the US National Heart, Lung, and Blood Institute funded Family Blood Pressure Program comprising 11 433 individuals recruited by hypertensive families. The results suggest that only one of the six SNPs might be associated with essential hypertension in Americans of European origin. This SNP shows a significant but opposite effect in Americans of Hispanic origin and no association in African Americans. The significance of the opposing effect estimates is unclear. No replication could be shown for hypertension status, but there are differences in study design. This attempted replication highlights that essential hypertension studies will require more comprehensive and larger genetic screens.

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Pressure/*genetics/physiology
  • Blood Pressure Determination
  • Child
  • *Family
  • Family Health
  • Female
  • *Genome-Wide Association Study
  • Humans
  • Hypertension/*genetics/physiopathology
  • Male
  • Middle Aged
  • Young Adult
Citation (ISO format)
EHRET, Georg Benedikt et al. Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program. In: European journal of human genetics, 2008, vol. 16, n° 12, p. 1507–1511. doi: 10.1038/ejhg.2008.102
Updates (1)
ISSN of the journal1018-4813

Technical informations

Creation03/27/2012 9:23:22 AM
First validation03/27/2012 9:23:22 AM
Update time03/14/2023 5:20:22 PM
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