Drawing on the mood-behavior model (G. H. E. Gendolla, 2000), 2 experiments examined moods’ informational impact on effort-related cardiovascular response. After being induced into positive versus negative moods, participants performed a memory task (Experiment 1) or a letter-cancellation task (Experiment 2). Half the participants received a cue that their mood could have been manipulated. As expected, both studies found stronger reactivity of systolic blood pressure in a negative mood than in a positive mood when no cue was provided. This effect diminished in the cue conditions. Additionally, achievement corresponded to systolic blood pressure reactivity (Experiment 1), the cue manipulation had no effect on mood, and mood had a congruency effect on subjective task difficulty in the no-cue conditions (Experiment 2).