Urological cancers are substantial burden for public health worldwide, due to their considerable incidence, morbidity and mortality. The cornerstone of an effective disease management is an appropriate diagnostic strategy and early detection. Based on the data from the population-based Geneva cancer registry, this article aimed to report epidemiological trends in urological cancers in Geneva from the last 26 years. Furthermore, it underlines the central role of all practitioners in identifying patients at risk and addressing them to the appropriate diagnostic pathway. This article enables us to take a step back from our current clinical practice in order to highlight their challenges and opportunities and find areas of improvement.